单细胞RNA测序揭示植入前非整倍体胚胎的异常谱系分化 - Suppr | 超能文献

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单细胞RNA测序揭示植入前非整倍体胚胎的异常谱系分化 - Suppr | 超能文献

Abnormal lineage differentiation of peri-implantation aneuploid embryos revealed by single-cell RNA sequencing.

作者信息

Chen Xueyao, Yu Hanwen, Yin Yu, Cai Bing, Shi Gaohui, Xu Yan, Rong Lujuan, Yu Xiu, Wang Boyan, Zhou Canquan, Wang Jichang, Ding Chenhui, Li Tianqing, Xu Yanwen

机构信息

Department of Gynecology & Obstetrics, Center for Reproductive Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, Guangdong, China.

出版信息

Clin Transl Med. 2025 May;15(5):e70326. doi: 10.1002/ctm2.70326.

DOI:10.1002/ctm2.70326

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056499/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/cd2683f53614/CTM2-15-e70326-g001.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/8a0801c2f85e/CTM2-15-e70326-g004.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/f113ac7011a1/CTM2-15-e70326-g002.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/6710c9c89eb7/CTM2-15-e70326-g003.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/cd2683f53614/CTM2-15-e70326-g001.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/8a0801c2f85e/CTM2-15-e70326-g004.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/f113ac7011a1/CTM2-15-e70326-g002.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/6710c9c89eb7/CTM2-15-e70326-g003.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0534/12056499/cd2683f53614/CTM2-15-e70326-g001.jpg

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本文引用的文献

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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells.乙酰辅酶 A 代谢维持组蛋白乙酰化，以促进人胎盘滋养层干细胞的融合。

Cell Stem Cell. 2024 Sep 5;31(9):1280-1297.e7. doi: 10.1016/j.stem.2024.07.003. Epub 2024 Jul 30.

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KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2.KAT8 介导的 H4K16ac 通过调节 CDX2 对于维持滋养层细胞自我更新和增殖是必不可少的。

Nat Commun. 2024 Jul 3;15(1):5602. doi: 10.1038/s41467-024-49930-6.

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EP300 facilitates human trophoblast stem cell differentiation.

EP300 促进人滋养层干细胞分化。

Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2217405120. doi: 10.1073/pnas.2217405120. Epub 2023 Jul 5.

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Metastasis-associated lung adenocarcinoma transcript 1 induces methyl-CpG-binding domain protein 4 in mice with recurrent spontaneous abortion caused by anti-phospholipid antibody positivity.转移相关肺腺癌转录本1在抗磷脂抗体阳性所致复发性自然流产小鼠中诱导甲基化CpG结合域蛋白4。

Placenta. 2023 Jun;137:38-48. doi: 10.1016/j.placenta.2023.04.008. Epub 2023 Apr 8.

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Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022.2022 年中国国家生物信息中心国家基因组学数据中心数据库资源。

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The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types.基因组序列档案家族：走向爆炸式的数据增长和多样化的数据类型。

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