Ceftazidime-avibactam activity against and .

BACKGROUND AND OBJECTIVES

Carbapenem-resistant Enterobacteriaceae (CRE) infections are extremely difficult to treat and have a high fatality rate. The study's primary goal was to determine the rate of ceftazidime-avibactam susceptibility using disc diffusion and E-Test, as well as to evaluate the agreement between the two methods.

MATERIALS AND METHODS

A total of 124 multidrug-resistant (including carbapenem) and isolates were included. Kirby Bauer's disc diffusion and E-test were used as the testing methods in this study.

RESULTS

In this study 37.5% and 33.9% of the isolates were susceptible to ceftazidime-avibactam by E test and Disc diffusion respectively. There were five isolates which produced discordant results. Among the 56 isolates there was 91% agreement between the two methods.

CONCLUSION

Among the discordant isolates the alarming disparity in zone size was a significant concern. Since CRE infections are very common, an economical and practical method for testing ceftazidime-avibactam susceptibility is needed in all the clinical microbiology laboratories as it is a last resort drug.