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营养不足对肺移植恢复的影响:一项荟萃分析。

Impact of Inadequate Nutrition in Lung Transplant Recovery: A Meta-Analysis.

作者信息

Cao Xu, Liu Chenxia, Liu Qiuyue, Gao Jian, Wang Yan, Yang Feng

机构信息

Department of Healthcare Ward, Peking University People's Hospital, Peking, China.

Department of Thoracic Surgery, Peking University People's Hospital, Peking, China.

出版信息

Iran J Public Health. 2025 Mar;54(3):454-464. doi: 10.18502/ijph.v54i3.18239.

Abstract

BACKGROUND

We aimed to appraise and compare the impact of inadequate nutrition in lung transplant recovery.

METHODS

Based on the inspection of the meta-analysis data, the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were derived by dichotomous random or fixed effect models. 6 papers with 1399 lung transplant who were available between 2020 and 2024 were comprised in this meta-analysis.

RESULTS

Frail had significantly higher hospital length of stay (MD, 2.80; 95% CI, 1.80-3.80, < 0.001), and all-cause mortality (OR, 2.33; 95% CI, 1.40-3.87, =0.001) compared to non-frail in subjects with lung transplant. However, no significant difference was found between frail and non-frail in intubation post-lung transplant (MD, 7.00; 95% CI, -17.52-31.52, =0.58), and intensive care unit length of stay (MD, -1.70; 95% CI, -4.53-1.14, =0.24) in subjects with lung transplant.

CONCLUSION

Using frail had significantly higher hospital length of stay, and all-cause mortality, however, no significant difference was found in intubation post-lung transplant, and intensive care unit length of stay compared to non-frail in subjects with lung transplant However, given that comparisons comprised a small number of studies, attention ought to be given to their values.

摘要

背景

我们旨在评估和比较营养不足对肺移植恢复的影响。

方法

基于对荟萃分析数据的检查,通过二分随机或固定效应模型得出比值比(OR)和平均差(MD)以及95%置信区间(CI)。本荟萃分析纳入了2020年至2024年间的6篇论文,共1399例肺移植患者。

结果

与非体弱的肺移植患者相比,体弱患者的住院时间显著更长(MD,2.80;95%CI,1.80 - 3.80,<0.001),全因死亡率更高(OR,2.33;95%CI,1.40 - 3.87,=0.001)。然而, 在肺移植后插管方面(MD,7.00;95%CI,-17.52 - 31.52,=0.58),以及肺移植患者的重症监护病房住院时间方面(MD,-1.70;95%CI,-4.53 - 1.14,=0.24),体弱和非体弱患者之间未发现显著差异。

结论

体弱的肺移植患者住院时间显著更长,全因死亡率更高,然而,与非体弱患者相比,在肺移植后插管和重症监护病房住院时间方面未发现显著差异。然而,鉴于比较的研究数量较少,应关注其价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4581/12051802/832f6ddc4325/IJPH-54-454-g001.jpg

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