Tao Zetong, Luo Zilong, Zou Zifeng, Ye Weicong, Hao Yanglin, Li Xiaohan, Zheng Kexiao, Wu Jie, Xia Jiahong, Zhao Yang, Wang Yongjun, Zhang Xi
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2025 Apr 22;16:1580369. doi: 10.3389/fimmu.2025.1580369. eCollection 2025.
Metabolic syndrome (MetS) is a group of symptoms that are characterized by abnormal changes in metabolic substances such as glucose, lipids, proteins, and bile acids. MetS is a common complication after organ transplantation and can further affect the survival and physiological function of the graft by reprograming the patient's immune environment. Additionally, MetS can influence the occurrence of post-transplant complications, such as infections. In recent years, research into the epidemiology and mechanisms of MetS has grown significantly. In this review, we summarize the mechanisms of MetS after transplantation and the mechanisms of hyperglycemia, insulin resistance, hyperlipidemia, abnormal bile acids, and abnormal amino acids on the body's immune cells as related to the effect of metabolic disorders on immune rejection after liver, kidney, heart, skin and other organ transplantation. Finally, we provide an overview of current treatment strategies and offer insights into potential future therapies for managing MetS in transplant recipients.
代谢综合征（MetS）是一组以葡萄糖、脂质、蛋白质和胆汁酸等代谢物质的异常变化为特征的症状。MetS是器官移植后常见的并发症，可通过重新编程患者的免疫环境进一步影响移植物的存活和生理功能。此外，MetS可影响移植后并发症的发生，如感染。近年来，对MetS的流行病学和机制的研究显著增加。在本综述中，我们总结了移植后MetS的机制，以及高血糖、胰岛素抵抗、高脂血症、胆汁酸异常和氨基酸异常对机体免疫细胞的机制，这些机制与肝脏、肾脏、心脏、皮肤和其他器官移植后代谢紊乱对免疫排斥反应的影响有关。最后，我们概述了当前的治疗策略，并对未来管理移植受者MetS的潜在治疗方法提供见解。
