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双重麻烦:免疫功能低下宿主中的利什曼病和巨细胞病毒性结肠炎

Double Trouble: Leishmaniasis and Cytomegalovirus Colitis in an Immunocompromised Host.

作者信息

Alghaythi Saleh, Almuhaidb Aymen, Al-Bawardy Badr

机构信息

Department of Internal Medicine, Division of Gastroenterology and Hepatology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.

College of Medicine, Al-Faisal University, Riyadh, Saudi Arabia.

出版信息

ACG Case Rep J. 2025 May 5;12(5):e01687. doi: 10.14309/crj.0000000000001687. eCollection 2025 May.

Abstract

Leishmaniasis is endemic in several areas of the world. It is a chronic protozoan disease transmitted through the bite of the Phlebotomus fly. Unusual localizations of visceral leishmaniasis are extremely rare and are described in immunocompromised patients. We present a case of a 73-year-old man, postliving nonrelated kidney transplant who complained of melena, fatigue, and weight loss. Gastroscopy showed a large ulcer at the lesser curvature of the stomach, and biopsies demonstrated severe ulceration with superimposed fungal organisms. Colonoscopy showed a polyp in the transverse colon, and histopathological examination revealed cytomegalovirus colitis with superimposed leishmaniasis.

摘要

利什曼病在世界上的几个地区呈地方性流行。它是一种通过白蛉叮咬传播的慢性原生动物疾病。内脏利什曼病的不寻常定位极为罕见,多见于免疫功能低下的患者。我们报告一例73岁男性病例,该患者为非亲属活体肾移植术后,主诉有黑便、疲劳和体重减轻。胃镜检查显示胃小弯处有一个大溃疡,活检显示严重溃疡并伴有真菌叠加感染。结肠镜检查显示横结肠有一个息肉,组织病理学检查显示巨细胞病毒性结肠炎并伴有利什曼病叠加感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/546c/12055041/e1660625894a/ac9-12-e01687-g001.jpg

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Co-Infection of Cytomegalovirus and Leishmania without Splenomegaly Resulting in Immunosuppression in an Hiv-Negative Patient.
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