Programa de Estudio y Control de Enfermedades Tropicales-PECET, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Transfusion. 2011 Sep;51(9):1919-23. doi: 10.1111/j.1537-2995.2011.03092.x. Epub 2011 Mar 10.
Transfusion-transmitted leishmaniasis is an increasing problem in areas where visceral and cutaneous leishmaniases are endemic.
This article reports a case of transfusion-transmitted fatal visceral leishmaniasis (VL) caused by Leishmania (Leishmania) mexicana in a 42-year-old male resident of northwestern Colombia who after developing a terminal renal failure due to lupus nephritis received a renal transplant and multiple transfusions.
Multiple intracellular Leishmania amastigotes were demonstrated in both renal biopsy and marrow aspirates. Cultures of the parasite were obtained in NNN medium and the identification of the species was done both by direct immunofluorescence and polymerase chain reaction-restriction fragment length polymorphism.
This is the first report of a VL case produced by L. (L.) mexicana in Colombia, which usually is a dermotropic species. Our report suggests that although leishmaniasis is transmitted by the bite of phlebotomine sand flies, Leishmania parasite may be transmitted by blood transfusion, complicating the clinical course of organ transplant and being fatal.
在内脏利什曼病和皮肤利什曼病流行的地区，经输血传播的利什曼病是一个日益严重的问题。
本文报告了一例由墨西哥利什曼原虫引起的致命性输血相关内脏利什曼病（VL）病例，患者为哥伦比亚西北部的一名 42 岁男性居民，因狼疮性肾炎导致终末期肾衰竭接受了肾移植和多次输血。
在肾活检和骨髓抽吸物中均发现了多个细胞内利什曼无鞭毛体。在 NNN 培养基中获得寄生虫培养物，并通过直接免疫荧光和聚合酶链反应-限制性片段长度多态性进行种属鉴定。
这是哥伦比亚首例由 L.（L.）mexicana 引起的 VL 病例报告，通常该物种为皮肤利什曼原虫。我们的报告表明，尽管利什曼病是通过白蛉的叮咬传播的，但利什曼原虫也可能通过输血传播，使器官移植的临床过程复杂化，并导致致命后果。
