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经口内镜下肌切开术治疗贲门失弛缓症患者的临床疗效。

Clinical efficacy of peroral endoscopic myotomy treatment performed in patients diagnosed with achalasia.

作者信息

Abayli Bahri, Ozer Ali Ilker, Kuvvetli Adnan, Biricik Serdar, Avci Begum Seyda, Demir Ozan, Felek Duygu, Sahan Ozge, Tugcan Mustafa Oguz, Sumbul Hilmi Erdem, Avci Akkan

机构信息

Department of Gastroenterology, Seyhan State Hospital, Adana, Turkiye.

Department of Emergency Medicine, University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkiye.

出版信息

North Clin Istanb. 2025 Apr 24;12(2):211-215. doi: 10.14744/nci.2024.08466. eCollection 2025.

DOI:10.14744/nci.2024.08466
PMID:40330515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12050994/
Abstract

OBJECTIVE

Achalasia is a movement disorder of the esophagus that continues with chest pain, dysphagia, weight loss, regurgitation of undigested foods, recurrent aspiration and night cough.

METHODS

Weight loss, presence of dysphagia, presence of retrosternal pain and regurgitation were recorded before POEM treatment and preoperative Eckardt Score was calculated and recorded. Patients were recorded at the 6 month after POEM treatment recording weight loss, dysphagia presence, retrosternal pain and regurgitation presence and calculating postoperative Eckardt score.

RESULTS

The change between the postoperative and preoperative values of the patients was calculated as ∆ value. As a result of the examination, no significant difference was found between the values ∆weight loss, ∆dysphagia, ∆retrosternal pain, ∆regurgitation and ∆Eckardt score and gender variable (respectively, p=0.112; p=0.412; p=0.619; p=0.171; p=0.092). Postoperative weight loss, dysphagia, retrosternal pain, regurgitation and Eckardt score values were found to be lower than preoperative values. (respectively, p<0.001;p<0.001; p<0.001; p<0.001; p<0.001).

CONCLUSION

Peroral endoscopic myotomy treatment is an effective treatment method with its being more reliable, lower complication risk, being less invasive and with postprocedural and clinical results.

摘要

目的

贲门失弛缓症是一种食管运动障碍性疾病,常伴有胸痛、吞咽困难、体重减轻、未消化食物反流、反复误吸及夜间咳嗽。

方法

记录经口内镜下肌切开术(POEM)治疗前的体重减轻情况、吞咽困难的存在情况、胸骨后疼痛的存在情况及反流情况,并计算和记录术前埃卡德特评分。在POEM治疗后6个月记录患者的体重减轻情况、吞咽困难的存在情况、胸骨后疼痛的存在情况及反流情况,并计算术后埃卡德特评分。

结果

计算患者术后与术前值之间的变化作为∆值。检查结果显示,∆体重减轻、∆吞咽困难、∆胸骨后疼痛、∆反流及∆埃卡德特评分与性别变量之间均无显著差异(分别为p = 0.112;p = 0.412;p = 0.619;p = 0.171;p = 0.092)。术后体重减轻、吞咽困难、胸骨后疼痛、反流及埃卡德特评分值均低于术前值。(分别为p < 0.001;p < 0.001;p < 0.001;p < 0.001;p < 0.001)。

结论

经口内镜下肌切开术治疗是一种有效的治疗方法,具有更高的可靠性、更低的并发症风险、更小的侵入性以及良好的术后和临床效果。

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本文引用的文献

1
POEM: clinical outcomes beyond 5 years.POEM:5 年以上的临床结果。
Surg Endosc. 2021 Oct;35(10):5709-5716. doi: 10.1007/s00464-020-08031-3. Epub 2021 Jan 4.
2
Accuracy of Achalasia Quality of Life and Eckardt scores for assessment of clinical improvement post treatment for achalasia.贲门失弛缓症生活质量和 Eckardt 评分评估贲门失弛缓症治疗后临床改善的准确性。
Dis Esophagus. 2021 Feb 10;34(2). doi: 10.1093/dote/doaa080.
3
ACG Clinical Guidelines: Diagnosis and Management of Achalasia.ACG 临床指南:贲门失弛缓症的诊断与管理。
Am J Gastroenterol. 2020 Sep;115(9):1393-1411. doi: 10.14309/ajg.0000000000000731.
4
Outcomes of Laparoscopic Heller Myotomy for Achalasia: 22-Year Experience.腹腔镜下贲门失弛缓症Heller肌切开术的治疗结果:22年经验
J Gastrointest Surg. 2020 Jun;24(6):1411-1416. doi: 10.1007/s11605-020-04586-7. Epub 2020 Apr 16.
5
Comparative efficacy of per-oral endoscopic myotomy and Heller myotomy in patients with achalasia: a meta-analysis.经口内镜下肌切开术与 Heller 肌切开术治疗贲门失弛缓症的疗效比较:一项荟萃分析。
Gastrointest Endosc. 2019 Oct;90(4):546-558.e3. doi: 10.1016/j.gie.2019.05.046. Epub 2019 Jun 10.
6
Evaluation and Management of Premalignant Conditions of the Esophagus: A Systematic Survey of International Guidelines.食管癌前病变的评估和管理:国际指南的系统调查。
J Clin Gastroenterol. 2019 Oct;53(9):627-634. doi: 10.1097/MCG.0000000000001247.
7
The 2018 ISDE achalasia guidelines.2018年国际吞咽障碍食管动力学会贲门失弛缓症指南。
Dis Esophagus. 2018 Sep 1;31(9). doi: 10.1093/dote/doy071.
8
Timed Barium Swallow: Diagnostic Role and Predictive Value in Untreated Achalasia, Esophagogastric Junction Outflow Obstruction, and Non-Achalasia Dysphagia. timed 钡吞咽:未经治疗的贲门失弛缓症、食管胃结合部流出道梗阻和非贲门失弛缓症性吞咽困难的诊断作用和预测价值。
Am J Gastroenterol. 2018 Feb;113(2):196-203. doi: 10.1038/ajg.2017.370. Epub 2017 Dec 19.
9
Comparison of outcomes of laparoscopic Heller myotomy versus per-oral endoscopic myotomy for management of achalasia.腹腔镜Heller肌切开术与经口内镜下肌切开术治疗贲门失弛缓症的疗效比较。
Proc (Bayl Univ Med Cent). 2017 Oct;30(4):419-423. doi: 10.1080/08998280.2017.11930212.
10
Peroral endoscopic myotomy versus surgical myotomy for primary achalasia: single-center, retrospective analysis of 74 patients.经口内镜下肌切开术与手术肌切开术治疗原发性贲门失弛缓症:74例患者的单中心回顾性分析
Dis Esophagus. 2017 Aug 1;30(8):1-7. doi: 10.1093/dote/dox028.