Annebäck Matilda, Wachtmeister Sofia, Hedberg Jakob, Stålberg Peter, Norlén Olov
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
BJS Open. 2025 May 7;9(3). doi: 10.1093/bjsopen/zraf032.
In recent years, several studies have shown that permanent hypoparathyroidism has a negative impact on health-related quality of life. However, these results could have been affected by short-term follow-up, selection bias and confounding factors. The aim of this study was to investigate health-related quality of life in patients with and without permanent hypoparathyroidism after total thyroidectomy for benign thyroid disease, using a strict definition of permanent hypoparathyroidism and long-term follow-up data.
All patients who underwent total thyroidectomy for benign thyroid disease in a region of Sweden between 1 January 2005 and 31 December 2015 were assessed for eligibility. Eligible patients were invited to participate in the study through a letter on 26 August 2021. The 36-item Short Form Health Survey version 2 was used to compare health-related quality of life in patients with and without permanent hypoparathyroidism.
Of 1636 patients, 1483 patients were invited to participate in the study. In total, 716 (48.3%) patients answered the Short Form Health Survey questionnaire and were included in the study cohort. Mean(s.d.) follow-up was 10.9(3.2) years. Patients with and without permanent hypoparathyroidism did not differ in baseline characteristics, with the exception that patients with permanent hypoparathyroidism were younger. There were no evident differences in health-related quality of life between the two groups, encompassing all health domains and summary component scores (P > 0.05).
No difference in health-related quality of life was found between patients with and without permanent hypoparathyroidism after total thyroidectomy on long-term follow-up. These results challenge previous findings and highlight the need for comprehensive, long-term studies to better understand the impact of this condition on health-related quality of life.
近年来，多项研究表明，永久性甲状旁腺功能减退对健康相关生活质量有负面影响。然而，这些结果可能受到短期随访、选择偏倚和混杂因素的影响。本研究的目的是使用永久性甲状旁腺功能减退的严格定义和长期随访数据，调查因良性甲状腺疾病行全甲状腺切除术后有和无永久性甲状旁腺功能减退患者的健康相关生活质量。
对2005年1月1日至2015年12月31日期间在瑞典某地区因良性甲状腺疾病接受全甲状腺切除术的所有患者进行资格评估。符合条件的患者于2021年8月26日通过信件邀请参加研究。使用36项简明健康调查问卷第2版比较有和无永久性甲状旁腺功能减退患者的健康相关生活质量。
1636例患者中，1483例患者被邀请参加研究。共有716例（48.3%）患者回答了简明健康调查问卷并被纳入研究队列。平均（标准差）随访时间为10.9（3.2）年。有和无永久性甲状旁腺功能减退的患者在基线特征上无差异，只是永久性甲状旁腺功能减退的患者更年轻。两组在健康相关生活质量方面没有明显差异，涵盖所有健康领域和综合成分得分（P>0.05）。
长期随访发现因良性甲状腺疾病行全甲状腺切除术后有和无永久性甲状旁腺功能减退的患者在健康相关生活质量方面没有差异。这些结果挑战了先前的研究结果，并强调需要进行全面的长期研究，以更好地了解这种疾病对健康相关生活质量的影响。
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