Golonka Iwona, Łukasiewicz Izabela W, Sebastiańczyk Aleksandra, Greber Katarzyna E, Sawicki Wiesław, Musiał Witold
Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Int J Mol Sci. 2025 Apr 8;26(8):3472. doi: 10.3390/ijms26083472.
is one of the most common skin diseases, and its development is closely linked to the overgrowth of the bacterium . More than half of the strains of this bacterium are resistant to antibiotics, which has prompted scientists to look for alternatives, such as antibacterial peptides, that can replace traditional drugs. Due to its antioxidant properties, ascorbic acid may be a promising ally in the treatment of acne. The aim of our study was to evaluate the effect of peptide (KWK)-KWWW-NH in the presence of ascorbic acid (AA) and its derivative (3-O-ethyl-L-ascorbic acid, EAA) on the stability and organization of phosphatidylinositol monolayers (PI) at temperatures of 25-35 °C. This study showed that the monolayers were in the expanded liquid state (35.28-49.95 mN/m) or in the transition between the expanded liquid and condensed phases (51.50-57.49 mN/m). Compression and decompression isotherms indicated the highest flexibility of the PI + P5 system, where the compression reversibility coefficient of isotherm values ranged from 80.59% to 97.77% and increased for each loop with increasing temperature. At 35 °C, the surface pressure of the monolayer in the PI + P5, PI + P5 + AA and PI + P5 + EAA systems changed less with time.
是最常见的皮肤疾病之一，其发展与该细菌的过度生长密切相关。这种细菌超过一半的菌株对抗生素具有抗性，这促使科学家寻找可替代传统药物的物质，如抗菌肽。由于其抗氧化特性，抗坏血酸可能是治疗痤疮的一种有前景的辅助物质。我们研究的目的是评估肽（KWK）-KWWW-NH在抗坏血酸（AA）及其衍生物（3-O-乙基-L-抗坏血酸，EAA）存在的情况下，于25 - 35°C温度下对磷脂酰肌醇单层（PI）稳定性和组织的影响。这项研究表明，单层处于膨胀液态（35.28 - 49.95 mN/m）或处于膨胀液态与凝聚相之间的转变状态（51.50 - 57.49 mN/m）。压缩和解压缩等温线表明PI + P5系统具有最高的柔韧性，其中等温线值的压缩可逆系数范围为80.59%至97.77%，并且随着温度升高每个循环都会增加。在35°C时，PI + P5、PI + P5 + AA和PI + P5 + EAA系统中单层的表面压力随时间变化较小。
