Guo Yu, Wang Lu, Huang Jun-Qing, Lu Mu-Wen, Yang Song-Hong
School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Int J Mol Sci. 2025 Apr 9;26(8):3530. doi: 10.3390/ijms26083530.
Current disposal methods for pomegranate peel (PP) waste are inadequate, resulting in environmental pollution. Given PP's therapeutic potential in alleviating irritable bowel syndrome (IBS), elucidating its bioactive mechanisms is critical to guide its development into dietary supplements and promote sustainable recycling. In this study, bioinformatics and network analysis were employed to identify active compounds, key targets, and signaling pathways associated with PP's therapeutic effects. We identified 39 bioactive compounds (primarily polyphenols) and 106 key targets linked to IBS. Network analyses revealed that PP polyphenols mitigate oxidative stress and inflammation, modulate estrogen receptors to enhance gastrointestinal motility, and regulate ferroptosis. These findings underscore PP's potential as a therapeutic agent for IBS and provide a framework for repurposing food-processing byproducts.
目前石榴皮（PP）废弃物的处理方法并不完善，导致了环境污染。鉴于石榴皮在缓解肠易激综合征（IBS）方面具有治疗潜力，阐明其生物活性机制对于将其开发成膳食补充剂并促进可持续回收利用至关重要。在本研究中，我们采用生物信息学和网络分析来确定与石榴皮治疗效果相关的活性化合物、关键靶点和信号通路。我们鉴定出了39种生物活性化合物（主要为多酚类）以及106个与肠易激综合征相关的关键靶点。网络分析显示，石榴皮中的多酚可减轻氧化应激和炎症反应，调节雌激素受体以增强胃肠蠕动，并调控铁死亡。这些发现突出了石榴皮作为肠易激综合征治疗药物的潜力，并为食品加工副产品的重新利用提供了一个框架。
