Škrlec Ivana, Biloglav Zrinka, Lešić Davor, Talapko Jasminka, Žabić Igor, Katalinić Darko
Faculty of Dental Medicine and Health, University J. J. Strossmayer Osijek, 31000 Osijek, Croatia.
Department of Medical Statistics, Epidemiology and Medical Informatics, School of Public Health Andrija Štampar, 10000 Zagreb, Croatia.
Int J Mol Sci. 2025 Apr 12;26(8):3667. doi: 10.3390/ijms26083667.
Hashimoto's thyroiditis (HT) is an autoimmune disorder of the thyroid gland characterized by chronic inflammation, which in most cases results in hypothyroidism. The melatonin receptor MTNR1B is sporadically expressed in the thyroid gland. It modulates immune responses, and alterations in the melatonin-MTNR1B receptor signaling pathway may play a role in developing autoimmune diseases. Obesity worsens the severity and progression of some autoimmune diseases and reduces treatment efficacy. This study aimed to investigate the association of gene polymorphisms (rs10830963, rs1387153, and rs4753426) with HT with regards to the body mass index (BMI). Patients with HT were categorized into normal weight BMI ≤ 25 kg/m and overweight/obese BMI > 25 kg/m groups. This study included 115 patients with a clinical-, ultrasound-, and laboratory-confirmed diagnosis of HT (64 normal-weight patients and 51 overweight/obese patients) with a mean age of 43 ± 12 years. The results showed that specific polymorphisms are associated with obesity in HT patients. BMI was found to be associated with the rs10830963 polymorphism, and the G allele and GG genotype of the rs10830963 polymorphism were more common in overweight/obese HT patients. Furthermore, the results suggest that genetic factors associated with BMI play a role in developing HT and open new possibilities for personalized treatment approaches.
桥本甲状腺炎（HT）是一种甲状腺自身免疫性疾病，其特征为慢性炎症，在大多数情况下会导致甲状腺功能减退。褪黑素受体MTNR1B在甲状腺中偶尔表达。它调节免疫反应，褪黑素-MTNR1B受体信号通路的改变可能在自身免疫性疾病的发生中起作用。肥胖会加重一些自身免疫性疾病的严重程度和进展，并降低治疗效果。本研究旨在探讨基因多态性（rs10830963、rs1387153和rs4753426）与HT在体重指数（BMI）方面的关联。HT患者被分为正常体重BMI≤25kg/m和超重/肥胖BMI>25kg/m组。本研究纳入了115例经临床、超声和实验室确诊为HT的患者（64例正常体重患者和51例超重/肥胖患者），平均年龄为43±12岁。结果表明，特定的多态性与HT患者的肥胖有关。发现BMI与rs10830963多态性有关，rs10830963多态性的G等位基因和GG基因型在超重/肥胖的HT患者中更为常见。此外，结果表明与BMI相关的遗传因素在HT的发生中起作用，并为个性化治疗方法开辟了新的可能性。
