心脏手术中使用的心脏停搏液对心肌保护作用的比较。
Comparison of the effect of cardioplegic solutions used in cardiac surgery on myocardial protection.
作者信息
Padak Mahmut, Dikme Reşat, Ersöz Ezhar, Hacanlı Yasemin
机构信息
Harran University, Faculty of Health Sciences, Department of Perfusion - Şanlıurfa, Turkey.
Harran University, Vocational School of Health Services, Dialysis Programme - Şanlıurfa, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2025 May 2;71(3):e20241451. doi: 10.1590/1806-9282.20241451. eCollection 2025.
OBJECTIVE
The aim of this retrospective study was to evaluate the effects of cardioplegic solutions on myocardial protection factors in patients undergoing cardiac surgery with cardiopulmonary bypass and to evaluate the relationship between these effects and early clinical outcomes.
METHODS
A total of 78 patients were included in the study. The data of patients who received del Nido cardioplegia (Group 1; n=39) and blood cardioplegia (Group 2; n=39) during the operation were grouped and compared. Preoperative and postoperative routine parameters such as creatine phosphokinase, troponin I, C-reactive protein, and demographic data were recorded, and statistical analyses were performed.
RESULTS
Perfusion time, cross-clamp time, act pump, preoperative C-reactive protein, preoperative creatine phosphokinase, preoperative troponin I, postoperative C-reactive protein, postoperative creatine phosphokinase, postoperative troponin I values were significantly different between del Nido and blood groups (p<0.05).
CONCLUSION
Del Nido cardioplegia provided myocardial protection and early postoperative favorable results compared to blood cardioplegia, which may make it a viable option for conventional cardiopulmonary bypass.
目的
本回顾性研究旨在评估心脏停搏液对接受体外循环心脏手术患者心肌保护因子的影响，并评估这些影响与早期临床结局之间的关系。
方法
本研究共纳入78例患者。将手术期间接受德尔尼多停搏液（第1组；n = 39）和血液停搏液（第2组；n = 39）的患者数据进行分组并比较。记录术前和术后的常规参数，如肌酸磷酸激酶、肌钙蛋白I、C反应蛋白以及人口统计学数据，并进行统计分析。
结果
德尔尼多组和血液组之间的灌注时间、主动脉阻断时间、体外循环时间、术前C反应蛋白、术前肌酸磷酸激酶、术前肌钙蛋白I、术后C反应蛋白、术后肌酸磷酸激酶、术后肌钙蛋白I值存在显著差异（p < 0.05）。
结论
与血液停搏液相比，德尔尼多停搏液提供了心肌保护并在术后早期取得了良好效果，这可能使其成为传统体外循环的一个可行选择。
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