Vianello Elena, Beltrami Antonio P, Aleksova Aneta, Janjusevic Milijana, Fluca Alessandra L, Corsi Romanelli Massimiliano M, La Sala Lucia, Dozio Elena
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
Experimental Laboratory for Research on Organ Damage Biomarkers, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy.
Int J Mol Sci. 2025 Apr 14;26(8):3707. doi: 10.3390/ijms26083707.
The AGE (advanced glycation end-products)-RAGE (receptor for AGE) system is a pro-inflammatory pathway that contributes to the pathogenesis of obesity and obesity-related cardiovascular disorders (CVD). Circulating AGE and the soluble form of RAGE (sRAGE) has been suggested as a potential biomarker of CVD related to obesity. In this study, we aim to (1) summarize the current knowledge about the role of obesity in the onset and progression of CVD, (2) discuss the role of the AGE-RAGE system as a pathway promoting obesity and linking obesity to CVD, and (3) highlight available strategies for reducing AGE-RAGE system activation and the associated beneficial effects.
晚期糖基化终末产物（AGE）- 晚期糖基化终末产物受体（RAGE）系统是一条促炎途径，它在肥胖症及肥胖相关心血管疾病（CVD）的发病机制中发挥作用。循环中的AGE及RAGE的可溶性形式（sRAGE）已被认为是与肥胖相关的CVD的潜在生物标志物。在本研究中，我们旨在：（1）总结目前关于肥胖在CVD发生和发展中作用的知识；（2）讨论AGE-RAGE系统作为促进肥胖并将肥胖与CVD联系起来的途径的作用；（3）强调减少AGE-RAGE系统激活的可用策略及其相关有益效果。
