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晚期糖基化终末产物（AGE）的AGE系统受体（RAGE）：连接肥胖与心血管疾病的炎症途径。

The Advanced Glycation End-Products (AGE)-Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases.

作者信息

Vianello Elena, Beltrami Antonio P, Aleksova Aneta, Janjusevic Milijana, Fluca Alessandra L, Corsi Romanelli Massimiliano M, La Sala Lucia, Dozio Elena

机构信息

Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.

Experimental Laboratory for Research on Organ Damage Biomarkers, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy.

出版信息

Int J Mol Sci. 2025 Apr 14;26(8):3707. doi: 10.3390/ijms26083707.

DOI:10.3390/ijms26083707
PMID:40332316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12028226/
Abstract

The AGE (advanced glycation end-products)-RAGE (receptor for AGE) system is a pro-inflammatory pathway that contributes to the pathogenesis of obesity and obesity-related cardiovascular disorders (CVD). Circulating AGE and the soluble form of RAGE (sRAGE) has been suggested as a potential biomarker of CVD related to obesity. In this study, we aim to (1) summarize the current knowledge about the role of obesity in the onset and progression of CVD, (2) discuss the role of the AGE-RAGE system as a pathway promoting obesity and linking obesity to CVD, and (3) highlight available strategies for reducing AGE-RAGE system activation and the associated beneficial effects.

摘要

晚期糖基化终末产物（AGE）- 晚期糖基化终末产物受体（RAGE）系统是一条促炎途径，它在肥胖症及肥胖相关心血管疾病（CVD）的发病机制中发挥作用。循环中的AGE及RAGE的可溶性形式（sRAGE）已被认为是与肥胖相关的CVD的潜在生物标志物。在本研究中，我们旨在：（1）总结目前关于肥胖在CVD发生和发展中作用的知识；（2）讨论AGE-RAGE系统作为促进肥胖并将肥胖与CVD联系起来的途径的作用；（3）强调减少AGE-RAGE系统激活的可用策略及其相关有益效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dd/12028226/b95a59569879/ijms-26-03707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dd/12028226/4c2d7d15cd50/ijms-26-03707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dd/12028226/b95a59569879/ijms-26-03707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dd/12028226/4c2d7d15cd50/ijms-26-03707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dd/12028226/b95a59569879/ijms-26-03707-g002.jpg

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本文引用的文献

[1]
An overview of obesity-related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes.

Diabetes Obes Metab. 2025-4

[2]
Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product-receptor axis.

Mol Med. 2025-3-6

[3]
The soluble receptor for advanced glycation end products is independently associated with systolic blood pressure values and hypertension in children.

Nutr Metab Cardiovasc Dis. 2025-7

[4]
AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications.

Cardiovasc Drugs Ther. 2024-11-5

[5]
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial.

Cardiovasc Diabetol. 2024-10-14

[6]
Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases.

Biomedicines. 2024-9-19

[7]
Generation and Accumulation of Various Advanced Glycation End-Products in Cardiomyocytes May Induce Cardiovascular Disease.

Int J Mol Sci. 2024-7-3

[8]
Lycopene in Combination with Insulin Triggers Antioxidant Defenses and Increases the Expression of Components That Detoxify Advanced Glycation Products in Kidneys of Diabetic Rats.

Nutrients. 2024-5-23

[9]
Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial.

Nutr Diabetes. 2024-6-1

[10]
Assessment of EN-RAGE, sRAGE, and its isoforms: cRAGE, esRAGE in obese patients treated by moderate caloric restriction combined with physical activity conducted in hospital condition.

Cytokine. 2024-8

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