Ożga Kinga, Stepuch Paweł, Maciejewski Ryszard, Sadok Ilona
Department of Biomedicine and Environmental Research, Institute of Biological Sciences, Faculty of Medicine, Collegium Medicum, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, Poland.
II Department of Oncological Surgery with Subdivision of Minimal Invasive Surgery, Center of Oncology of the Lublin Region St. Jana z Dukli, Jaczewskiego 7, 20-090 Lublin, Poland.
Int J Mol Sci. 2025 Apr 14;26(8):3706. doi: 10.3390/ijms26083706.
Currently, gastric cancer treatment remains an enormous challenge and requires a multidisciplinary approach. Globally, the incidence and prevalence of gastric cancer vary, with the highest rates found in East Asia, Central Europe, and Eastern Europe. Early diagnosis is critical for successful surgical removal of gastric cancer, but the disease often develops asymptomatically. Therefore, many cases are diagnosed at an advanced stage, resulting in poor survival. Metastatic gastric cancer also has a poor prognosis. Therefore, it is urgent to identify reliable molecular disease markers and develop an effective medical treatment for advanced stages of the disease. This review summarizes potential prognostic or predictive markers of gastric cancer. Furthermore, the role of tryptophan metabolites from the kynurenine pathway as prognostic, predictive, and diagnostic factors of gastric cancer is discussed, as this metabolic pathway is associated with tumor immune resistance.
目前，胃癌治疗仍然是一项巨大挑战，需要多学科方法。在全球范围内，胃癌的发病率和患病率各不相同，东亚、中欧和东欧的发病率最高。早期诊断对于成功手术切除胃癌至关重要，但该疾病通常无症状发展。因此，许多病例在晚期才被诊断出来，导致生存率低下。转移性胃癌的预后也很差。因此，迫切需要确定可靠的分子疾病标志物，并开发针对该疾病晚期的有效药物治疗方法。本综述总结了胃癌潜在的预后或预测标志物。此外，还讨论了犬尿氨酸途径中色氨酸代谢产物作为胃癌预后、预测和诊断因素的作用，因为该代谢途径与肿瘤免疫抵抗相关。
