Nagao Yuko, Taguchi Akihiko, Ohta Yasuharu
Health Science Center, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.
Department of Endocrinology, Metabolism, Hematological Science and Therapeutics, Graduate School of Medicine, Yamaguchi University, 1-1-1, Minami Kogushi, Ube 755-8505, Japan.
Int J Mol Sci. 2025 Apr 15;26(8):3724. doi: 10.3390/ijms26083724.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic intestinal inflammation. Recent research has highlighted the significant interplay between IBD pathogenesis and circadian rhythms. This review synthesizes current evidence regarding circadian regulation in IBD, covering three main areas: (1) circadian rhythms in intestinal physiology, (2) circadian disruption patterns in IBD patients, and (3) the role of clock genes in IBD pathogenesis. We discuss how these findings may inform novel chronotherapeutic approaches for IBD treatment. Future research directions that could facilitate translation of chronobiological insights into clinical applications are also explored.
炎症性肠病（IBD）包括溃疡性结肠炎（UC）和克罗恩病（CD），其特征为慢性肠道炎症。近期研究突显了IBD发病机制与昼夜节律之间的重要相互作用。本综述综合了目前关于IBD中昼夜调节的证据，涵盖三个主要领域：（1）肠道生理学中的昼夜节律，（2）IBD患者的昼夜节律紊乱模式，以及（3）生物钟基因在IBD发病机制中的作用。我们讨论了这些发现如何为IBD治疗的新型时间治疗方法提供依据。还探讨了有助于将时间生物学见解转化为临床应用的未来研究方向。
