Gacuta Ewa, Ławicki Michał, Kulesza Monika, Ławicki Paweł, Kicman Aleksandra, Łubińska Emilia, Ławicki Sławomir
Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Waszyngtona 15B, 15-269 Bialystok, Poland.
Int J Mol Sci. 2025 Apr 18;26(8):3824. doi: 10.3390/ijms26083824.
Metalloproteinases (MMPs) play a significant role in cancer pathogenesis. We investigated the levels of MMP-7, MMP-26, MMP-3, and MMP-10 in comparison with the levels of a tumor marker (CA125) in the plasma of postmenopausal patients in early stages of endometrial cancer (EC) compared with control groups: patients with benign lesions () and healthy controls. Plasma MMP levels were determined by ELISA and CA125 by CMIA methods. The study showed that plasma MMP-7 levels were significantly higher in EC patients compared to both control groups, whereas MMP-3 and MMP-26 levels were significantly higher in EC patients than in healthy women. MMP-7 showed the highest diagnostic sensitivity (SE), specificity (SP), positive (PPV) and negative predictive value (NPV), and diagnostic power (AUC) compared to other MMPs or CA125 in EC patients overall and patients with stage I and II EC. A combined analysis showed higher SE, NPV, and AUC levels in total EC patients and stage I and II EC patients-with the highest values for the combination MMP-7+CA125 (96%, 92%, 95%; 95%, 96%, and 98%; 0.9420, 0.9158, and 0.9693, respectively) or MMP-26 with CA125 (86%, 86%, and 86%; 59%, 73%, 73%; 0.8219, 0.8086, and 0.8353, respectively). The results suggest the usefulness of MMPs, especially MMP-7 and MMP-26, in combined panels with CA125 in diagnosing EC patients.
金属蛋白酶（MMPs）在癌症发病机制中发挥着重要作用。我们研究了绝经后子宫内膜癌（EC）早期患者血浆中MMP-7、MMP-26、MMP-3和MMP-10的水平，并与肿瘤标志物（CA125）的水平进行比较，对照组为良性病变患者（）和健康对照者。采用酶联免疫吸附测定法（ELISA）测定血浆MMP水平，采用化学发光微粒子免疫分析法（CMIA）测定CA125水平。研究表明，与两个对照组相比，EC患者血浆MMP-7水平显著更高，而EC患者血浆MMP-3和MMP-26水平显著高于健康女性。总体而言，在EC患者以及I期和II期EC患者中，与其他MMP或CA125相比，MMP-7显示出最高的诊断敏感性（SE）、特异性（SP）、阳性预测值（PPV）和阴性预测值（NPV）以及诊断效能（AUC）。联合分析显示，总体EC患者以及I期和II期EC患者的SE、NPV和AUC水平更高——MMP-7与CA125联合时的值最高（分别为96%、92%、95%；95%、96%和98%；0.9420、0.9158和0.9693），或MMP-26与CA125联合时的值最高（分别为86%、86%和86%；59%、73%、73%；0.8219、0.8086和0.8353）。结果表明，MMPs，尤其是MMP-7和MMP-26，与CA125联合用于诊断EC患者具有实用性。
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