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微藻乙醇提取物在酒精性肝病中的有益作用。

The Beneficial Effects of Ethanol Extract of the Microalga in Alcoholic Liver Disease.

作者信息

Kim Dae Yoon, Shin Seung Cheol, Kim Gab Jung, Eom Jae-In, Han Cheol-Ho, Pan Cheol-Ho, Lee Jae Kwon

机构信息

College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Department of Biology Education, College of Education, Chungbuk National University, Cheongju 28160, Republic of Korea.

出版信息

Int J Mol Sci. 2025 Apr 18;26(8):3851. doi: 10.3390/ijms26083851.

DOI:10.3390/ijms26083851
PMID:40332498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12027534/
Abstract

Alcoholic liver disease (ALD) is a condition resulting from liver damage linked to excessive drinking over a brief duration. It poses a significant public health challenge globally, with its prevalence and morbidity rising annually due to escalating rates of alcohol abuse, which adversely affect human health. (PT), a diatom species of microalgae, is reported to possess active components that provide anti-inflammatory and antioxidant benefits. This study aimed to investigate the preventive and therapeutic effects of PT extract on ALD. To address our purpose, we used ethanol diet induced live disease model. Mice fed an ethanol diet showed less weight gain and higher levels of AST and ALT compared to those fed a regular diet. PT extract suppressed the inhibition of weight gain and the increase in AST/ALT levels caused by an ethanol diet. In addition, PT extract also prevented liver tissue damage caused by an ethanol diet. Thus, the effect of PT on ALD was found to be related to the inhibition of mitogen-activated protein kinase (MAP kinases) phosphorylation and TNF-α production.

摘要

酒精性肝病（ALD）是一种因短期内过度饮酒导致肝脏损伤而引发的疾病。它在全球范围内构成了重大的公共卫生挑战，由于酒精滥用率不断上升，其患病率和发病率逐年增加，对人类健康产生了不利影响。据报道，硅藻门的一种微藻——三角褐指藻（PT）含有具有抗炎和抗氧化作用的活性成分。本研究旨在探讨PT提取物对酒精性肝病的预防和治疗作用。为实现这一目的，我们使用了乙醇饮食诱导的肝病模型。与喂食常规饮食的小鼠相比，喂食乙醇饮食的小鼠体重增加较少，AST和ALT水平较高。PT提取物抑制了乙醇饮食导致的体重增加抑制和AST/ALT水平升高。此外，PT提取物还预防了乙醇饮食引起的肝组织损伤。因此，发现PT对酒精性肝病的作用与抑制丝裂原活化蛋白激酶（MAP激酶）磷酸化和肿瘤坏死因子-α产生有关。

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