College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
Department of Biology Education, College of Education, Chungbuk National University, Cheongju 28160, Republic of Korea.
Int J Mol Sci. 2024 Jun 6;25(11):6247. doi: 10.3390/ijms25116247.
Acute liver failure is an infrequent yet fatal condition marked by rapid liver function decline, leading to abnormalities in blood clotting and cognitive impairment among individuals without prior liver ailments. The primary reasons for liver failure are infection with hepatitis virus or overdose of certain medicines, such as acetaminophen. (PT), a type of microalgae known as a diatom species, has been reported to contain an active ingredient with anti-inflammatory and anti-obesity effects. In this study, we evaluated the preventive and therapeutic activities of PT extract in acute liver failure. To achieve our purpose, we used two different acute liver failure models: acetaminophen- and D-GalN/LPS-induced acute liver failure. PT extract showed protective activity against acetaminophen-induced acute liver failure through attenuation of the inflammatory response. However, we failed to demonstrate the protective effects of PT against acute liver injury in the D-GalN/LPS model. Although the PT extract did not show protective activity against two different acute liver failure animal models, this study clearly demonstrates the importance of considering the differences among animal models when selecting an acute liver failure model for evaluation.
急性肝衰竭是一种罕见但致命的病症，其特征是肝功能迅速下降，导致无先前肝脏疾病的个体出现凝血异常和认知障碍。肝衰竭的主要原因是感染肝炎病毒或过量使用某些药物，如对乙酰氨基酚。PT 是一种微藻，属于硅藻物种，据报道含有一种具有抗炎和抗肥胖作用的活性成分。在这项研究中，我们评估了 PT 提取物对急性肝衰竭的预防和治疗作用。为了达到我们的目的，我们使用了两种不同的急性肝衰竭模型：对乙酰氨基酚和 D-GalN/LPS 诱导的急性肝衰竭。PT 提取物通过减轻炎症反应显示出对乙酰氨基酚诱导的急性肝衰竭的保护活性。然而，我们未能证明 PT 对 D-GalN/LPS 模型中的急性肝损伤具有保护作用。尽管 PT 提取物对两种不同的急性肝衰竭动物模型没有表现出保护活性，但这项研究清楚地表明，在选择用于评估的急性肝衰竭模型时，考虑动物模型之间的差异非常重要。
