血浆致动脉粥样硬化指数与体重指数和2型糖尿病风险之间的关系：来自中国健康与养老追踪调查（CHARLS）的见解

Relationships between atherogenic index of plasma and body mass index with the risk of type 2 diabetes mellitus: insights from CHARLS.

作者信息

Chen Genghang, Liu Shaonan, Ouyang Wenwei, Yang Lihong, Chen Yu, Guo Xinfeng

机构信息

Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.

State Key Laboratory of Dampness, Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.

出版信息

Acta Diabetol. 2025 May 7. doi: 10.1007/s00592-025-02516-0.

DOI:10.1007/s00592-025-02516-0

PMID:40332562

Abstract

BACKGROUND

The complex relationship between obesity and dyslipidemia in type 2 diabetes mellitus (T2DM) remains an area of interest but is not fully understood. This study aimed to evaluate the intricate links between atherogenic index of plasma (AIP), body mass index (BMI), and T2DM risk.

METHODS

Based on data from the China Health and Retirement Longitudinal Study, this analysis comprised 6754 individuals aged 45 and over, free of T2DM in 2011. BMI and AIP were the exposures, with T2DM incidence as the primary focus. Logistic regression models generated odds ratios (ORs), and a thorough decomposition of BMI's impact on T2DM revealed natural indirect and direct effects. The study also examined the complex interactions and combined effects of these two exposures.

RESULTS

By the end of 2018, 972 individuals were diagnosed with T2DM. The AIP played a significant association in the relationship between BMI and T2DM, explaining 21.7% and 18.9% of the association in different BMI ranges. A significant additive effect was observed between BMI and AIP, with a relative excess risk due to interaction of 0.62. BMI ≥ 24.0 kg/m and AIP above the median together conferred the highest risk of T2DM, with an OR of 2.31 and a 95% confidence interval (CI) of 1.92-2.79.

CONCLUSION

Exposure to overweight/obesity or high AIP raises T2DM risk among Chinese ≥ 45 years, AIP partly mediates BMI-T2DM link.

摘要

背景

2型糖尿病（T2DM）中肥胖与血脂异常之间的复杂关系仍是一个备受关注的领域，但尚未完全明确。本研究旨在评估血浆致动脉粥样硬化指数（AIP）、体重指数（BMI）与T2DM风险之间的复杂联系。

方法

基于中国健康与养老追踪调查的数据，本分析纳入了2011年时年龄在45岁及以上且无T2DM的6754名个体。以BMI和AIP作为暴露因素，以T2DM发病率作为主要研究重点。逻辑回归模型生成比值比（OR），对BMI对T2DM影响的全面分解揭示了自然间接效应和直接效应。该研究还考察了这两种暴露因素的复杂相互作用和联合效应。

结果

截至2018年底，972人被诊断为T2DM。AIP在BMI与T2DM的关系中发挥了显著关联，在不同BMI范围内分别解释了该关联的21.7%和18.9%。观察到BMI与AIP之间存在显著的相加效应，交互作用导致的相对超额风险为0.62。BMI≥24.0 kg/m且AIP高于中位数共同赋予了最高的T2DM风险，OR为2.31，95%置信区间（CI）为1.92 - 2.79。