咖啡酸苯乙酯（CAPE）抑制精氨酸酶活性以及前鞭毛体和细胞内无鞭毛体的生长。
Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of Promastigotes and Intracellular Amastigotes.
作者信息
da Silva Edson Roberto, Mesquita André, do Carmo Maquiaveli Claudia
机构信息
Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil.
出版信息
Pathogens. 2025 Apr 15;14(4):384. doi: 10.3390/pathogens14040384.
Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against . CAPE exhibited IC values of 8.07 µM (95% CI, 6.79-9.62 µM) and 13.51 µM (95% CI, 10.71-17.16 µM) against promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited arginase in a non-competitive manner with a K value of 1.51 ± 0.04 µM. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis.
咖啡酸苯乙酯（CAPE）是许多植物产生的一种多酚，存在于红蜂胶和绿蜂胶中。在此，我们评估了这种天然产物对利什曼原虫的抗利什曼活性。CAPE对前鞭毛体和细胞内无鞭毛体的IC值分别为8.07 µM（95%置信区间，6.79 - 9.62 µM）和13.51 µM（95%置信区间，10.71 - 17.16 µM）。此外，CAPE以非竞争性方式抑制精氨酸酶，K值为1.51 ± 0.04 µM。这些结果突出了CAPE作为开发抗利什曼病新疗法的有前景先导化合物的潜力。
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