Gao Yingjun, Lou Yanfeng, Hui Yun, Chen Huan, Sang Hong, Liu Fang
Department of Dermatology, Jinling Hospital, Nanjing Medical University, Nanjing 210002, China.
Department of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.
Pathogens. 2025 Apr 7;14(4):358. doi: 10.3390/pathogens14040358.
Psoriasis is a prevalent and persistent inflammatory disorder with systemic manifestations. Emerging evidence implicates the gut microbiota in regulating inflammatory responses, metabolic pathways, and immune homeostasis. This review synthesizes current evidence on gut microbiota dysbiosis in psoriasis and evaluates the therapeutic potential of probiotics and fecal microbiota transplantation (FMT) in disease management. Following PRISMA guidelines, we systematically reviewed studies investigating gut microbiome profiles in psoriasis through the MEDLINE, EMBASE, and Web of Science databases (January 2015-December 2024). Included studies utilized 16S rRNA gene sequencing or metagenomic analyses for microbial characterization. Comparative analyses revealed distinct gut microbiota patterns in psoriasis patients compared with healthy controls, although specific microbial signatures exhibited inconsistencies across studies. Notably, interventions modulating gut microbiota composition-particularly probiotic supplementation-demonstrated measurable improvements in psoriasis severity scores and inflammatory markers. Gut microbiome modulation represents a promising therapeutic strategy for psoriasis; however, current evidence highlights the need for standardized microbial analysis methodologies and larger longitudinal studies to establish causality. Future research should prioritize the functional characterization of microbiota-host interactions to optimize therapeutic applications.
银屑病是一种常见且持续的炎症性疾病，具有全身表现。新出现的证据表明肠道微生物群在调节炎症反应、代谢途径和免疫稳态方面发挥作用。本综述综合了目前关于银屑病中肠道微生物群失调的证据，并评估了益生菌和粪便微生物群移植（FMT）在疾病管理中的治疗潜力。遵循PRISMA指南，我们通过MEDLINE、EMBASE和科学网数据库（2015年1月至2024年12月）系统地回顾了研究银屑病肠道微生物组概况的研究。纳入的研究利用16S rRNA基因测序或宏基因组分析来进行微生物特征分析。比较分析显示，与健康对照相比，银屑病患者的肠道微生物群模式不同，尽管特定的微生物特征在不同研究中存在不一致。值得注意的是，调节肠道微生物群组成的干预措施——特别是补充益生菌——在银屑病严重程度评分和炎症标志物方面显示出可测量的改善。肠道微生物组调节是银屑病一种有前景的治疗策略；然而，目前的证据强调需要标准化的微生物分析方法和更大规模的纵向研究来确定因果关系。未来的研究应优先对微生物群与宿主相互作用进行功能表征，以优化治疗应用。
