Wang Xiaomeng, Chen Zheng, Qiao Song, Zhu Qiming, Zuo Zongbao, Guo Birong
Department of Dermatology, The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Hefei, Anhui, China.
Department of Plastic Surgery, The Second People's Hospital of Anhui Province, Hefei, Anhui, China.
Indian J Dermatol. 2022 Sep-Oct;67(5):495-503. doi: 10.4103/ijd.ijd_297_22.
Psoriasis is an inflammatory skin disease. The correlation between intestinal microbiota and immune-mediated diseases makes scientists pay attention to the pathogenic role of microbiota.
The aim of this study was to identify the gut microbial composition of patients with psoriasis.
16S rRNA gene sequencing method was used to analyse the faecal samples which was collected from 28 moderately severe psoriasis patients and 21 healthy controls and was followed by the analysing of informatics methods.
No visible differences can be observed in the diversity of gut microbiota between the psoriasis and the healthy patients, but the composition of the gut microbiota illustrate significant distinction between these two groups. At the phylum level, compared to the healthy control group, the psoriasis group shows higher relative abundance of and lower relative abundance of ( < 0.05). At the genus level, were relatively less abundant in psoriasis patients, whereas were relatively more abundant in psoriasis group (all < 0.05). LefSe analysis (linear discriminant analysis effect size) indicated that and were potential biomarkers for psoriasis.
This study identified the intestinal microecological environment of patients with psoriasis and healthy people, proving that psoriasis patients have a remarkably disturbed microbiome, and found several biomarkers of intestinal microorganisms in patients with psoriasis.
银屑病是一种炎症性皮肤病。肠道微生物群与免疫介导疾病之间的相关性使科学家们关注微生物群的致病作用。
本研究旨在确定银屑病患者的肠道微生物组成。
采用16S rRNA基因测序方法分析从28例中度重度银屑病患者和21例健康对照者收集的粪便样本，并进行信息学方法分析。
银屑病患者与健康患者肠道微生物群的多样性未见明显差异，但两组肠道微生物群的组成存在显著差异。在门水平上，与健康对照组相比，银屑病组 的相对丰度较高，而 的相对丰度较低（ < 0.05）。在属水平上，银屑病患者中 相对较少，而银屑病组中 相对较多（均 < 0.05）。LefSe分析（线性判别分析效应大小）表明， 和 是银屑病的潜在生物标志物。
本研究确定了银屑病患者和健康人的肠道微生态环境，证明银屑病患者的微生物群存在明显紊乱，并发现了银屑病患者肠道微生物的几个生物标志物。
