Brusis T, Loennecken I
Laryngol Rhinol Otol (Stuttg). 1985 Jul;64(7):355-8.
50 previously unsuccessfully treated patients suffering from tinnitus were given local-anaesthesia-iontophoresis. By iontophoresis it is possible to build up an electric field, in which a local anaesthetic (lidocaine hydrochloride) is able to penetrate through the tympanic membrane. Experimentally it has been proven that this local anaesthetic has a direct effect on the inner ear. In contrast to intravenous and intratympanal application there are no toxic side effects when applying local-anaesthesia-iontophoresis. Tinnitus was reduced completely or partly in 31 patients after repeated application to one or both ears. No connection was seen between the success of therapy and the origin of the tinnitus. Treatment was unsuccessful in 19 cases. No serious side effects were seen. Local-anaesthesia-iontophoresis can be recommended as an attempt to treat tinnitus, especially in those cases who have not yet responded to drugs.
50名此前接受治疗但未成功的耳鸣患者接受了局部麻醉离子导入疗法。通过离子导入可以建立一个电场,在这个电场中局部麻醉剂(盐酸利多卡因)能够穿透鼓膜。实验证明,这种局部麻醉剂对内耳有直接作用。与静脉内和鼓室内给药相比,应用局部麻醉离子导入疗法时没有毒性副作用。在对一只或两只耳朵反复应用该疗法后,31名患者的耳鸣完全或部分减轻。治疗的成功与耳鸣的起源之间未发现关联。19例治疗未成功。未观察到严重的副作用。局部麻醉离子导入疗法可作为治疗耳鸣的一种尝试推荐,特别是在那些对药物尚未有反应的病例中。