Barak A J, Tuma D J, Beckenhauer H C
Life Sci. 1985 Sep 2;37(9):789-91. doi: 10.1016/0024-3205(85)90512-0.
The findings obtained in this laboratory and others over the past decade are discussed in order to formulate a thesis, indicating the adverse action of ethanol on a vital methylation process in the liver. Evidence is shown that the rat may have a means of compensating for this impairment in methylation whereas humans do not have this same ability to protect against this action of ethanol. These considerations may offer a basis of why rats are apparently more resistant to alcoholic liver injury than humans.
