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三乙醇铵氨基酸盐的植物毒性、细胞毒性及抗菌活性

Phytotoxicity, Cytotoxicity, and Antimicrobial Activity of Triethanolammonium Amino Acids Salts.

作者信息

Roman Barbara Hanna, Charęza Magdalena, Drozd Radosław, Sokołowska Martyna, Sobolewski Peter, Janus Ewa

机构信息

Department of Organic Chemical Technology and Polymer Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Pułaskiego 10, 70-322 Szczecin, Poland.

Department of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, Piastόw 45, 70-311 Szczecin, Poland.

出版信息

Molecules. 2025 Apr 11;30(8):1712. doi: 10.3390/molecules30081712.

DOI:10.3390/molecules30081712
PMID:40333600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12029836/
Abstract

The growing use of ionic liquids (ILs) necessitates an understanding of their environmental impact and toxicity levels. In this study, a series of amino acid-based ionic liquids containing the triethanolammonium (TEA) cation were evaluated for their biological activity against L., the mouse fibroblast cell line L929, a selection of gram-positive and gram-negative bacteria, and the yeast . The influence of amino acid anion structure on toxicity was also examined. Among the tested ionic liquids, [TEA][Asp] exhibited low toxicity toward , representing terrestrial plants, while [TEA][Phe] showed the lowest cytotoxicity. Regarding microbial activity, [TEA][Lys] demonstrated greater bactericidal effectiveness against than , while both [TEA][Lys] and [TEA][Arg] exhibited the strongest inhibitory effect against Our findings underscore the crucial role of IL salt composition in determining biological activity, highlighting the significance of interactions between IL components in shaping their potential effects.

摘要

离子液体（ILs）的使用日益广泛，因此有必要了解它们对环境的影响和毒性水平。在本研究中，对一系列含有三乙醇铵（TEA）阳离子的氨基酸基离子液体针对生菜、小鼠成纤维细胞系L929、多种革兰氏阳性和革兰氏阴性细菌以及酵母的生物活性进行了评估。还研究了氨基酸阴离子结构对毒性的影响。在所测试的离子液体中，[TEA][Asp]对代表陆生植物的生菜表现出低毒性，而[TEA][Phe]表现出最低的细胞毒性。关于微生物活性，[TEA][Lys]对金黄色葡萄球菌的杀菌效果比对大肠杆菌更强，而[TEA][Lys]和[TEA][Arg]对白色念珠菌均表现出最强的抑制作用。我们的研究结果强调了离子液体盐组成在决定生物活性方面的关键作用，突出了离子液体成分之间的相互作用在塑造其潜在影响方面的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/240318f09a3d/molecules-30-01712-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/ecb1ec1039f1/molecules-30-01712-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/4098ab0652a6/molecules-30-01712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/0064e46969c3/molecules-30-01712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/cb092b689467/molecules-30-01712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/e577da134bdc/molecules-30-01712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/78754f1488cb/molecules-30-01712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/0e77644dbe91/molecules-30-01712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/d5f28bc09742/molecules-30-01712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/c92e16fd75d8/molecules-30-01712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/5c109137f7f4/molecules-30-01712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/240318f09a3d/molecules-30-01712-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/ecb1ec1039f1/molecules-30-01712-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/4098ab0652a6/molecules-30-01712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/0064e46969c3/molecules-30-01712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/cb092b689467/molecules-30-01712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/e577da134bdc/molecules-30-01712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/78754f1488cb/molecules-30-01712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/0e77644dbe91/molecules-30-01712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/d5f28bc09742/molecules-30-01712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/c92e16fd75d8/molecules-30-01712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/5c109137f7f4/molecules-30-01712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdb6/12029836/240318f09a3d/molecules-30-01712-g010.jpg

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[1]
Phytotoxicity, Cytotoxicity, and Antimicrobial Activity of Triethanolammonium Amino Acids Salts.

Molecules. 2025-4-11

[2]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Evaluation of new L-amino acids triethanolammonium salts usability for controlling protease activity.

Int J Biol Macromol. 2023-3-15

[2]
Assessment of the toxicity and biodegradation of amino acid-based ionic liquids.

RSC Adv. 2019-4-1

[3]
The application of amino acid ionic liquids as additives in the ultrasound-assisted extraction of plant material.

RSC Adv. 2021-7-27

[4]
Ionic liquid-based antimicrobial materials for water treatment, air filtration, food packaging and anticorrosion coatings.

Adv Colloid Interface Sci. 2021-8

[5]
Ionic Liquids-A Review of Their Toxicity to Living Organisms.

Int J Mol Sci. 2021-5-25

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Sci Total Environ. 2021-9-10

[7]
Cholinium amino acid-based ionic liquids.

Biophys Rev. 2021-1-14

[8]
Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells.

Biomolecules. 2020-2-4

[9]
The Bacterial Cell Wall and Membrane-A Treasure Chest for Antibiotic Targets.

Subcell Biochem. 2019

[10]
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Microbiol Spectr. 2019-5

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