Yang JunRan, Zhou Zhenhua
Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China.
PLoS One. 2025 May 7;20(5):e0322990. doi: 10.1371/journal.pone.0322990. eCollection 2025.
Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide. This study aimed to analyze the risk factors associated with NAFLD progression by collecting and evaluating clinical data of NAFLD patients, providing a scientific basis for its prevention and treatment.
Clinical data of NAFLD patients from June 2015 to June 2016 were retrospectively collected, including gender, age, alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP),γ-glutamyltranspeptidase (GGT), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting blood glucose (FBG), and visceral fat area (VFA). All patients were stratified by gender and age, and logistic regression analysis was used to explore the risk factors for NAFLD disease progression.
ALT, TG, FBG, and VFA were identified as independent risk factors for NAFLD progression. Stratified analysis showed that in male patients, ALT, TG, and VFA were independent risk factors, whereas in female patients, TG, FBG, and VFA were identified as independent risk factors. Age-stratified analysis revealed that ALT, TG, and VFA were significant risk factors for progression in young and middle-aged patients. At the same time, age, ALT, TG, and FBG were substantial in elderly patients.
Different risk factors should be closely monitored in sex- and age-specific populations to prevent NAFLD progression effectively.
非酒精性脂肪性肝病（NAFLD）在全球范围内日益普遍。本研究旨在通过收集和评估NAFLD患者的临床数据，分析与NAFLD进展相关的危险因素，为其预防和治疗提供科学依据。
回顾性收集2015年6月至2016年6月NAFLD患者的临床数据，包括性别、年龄、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（GGT）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、空腹血糖（FBG）和内脏脂肪面积（VFA）。所有患者按性别和年龄分层，采用逻辑回归分析探讨NAFLD疾病进展的危险因素。
ALT、TG、FBG和VFA被确定为NAFLD进展的独立危险因素。分层分析显示，在男性患者中，ALT、TG和VFA是独立危险因素，而在女性患者中，TG、FBG和VFA被确定为独立危险因素。年龄分层分析显示，ALT、TG和VFA是中青年患者进展的显著危险因素。同时，年龄、ALT、TG和FBG在老年患者中也很重要。
应在特定性别和年龄人群中密切监测不同的危险因素，以有效预防NAFLD进展。
