Carpenter David J, Peluso Chris, Hilton Christie, Coopey Suzanne B, Gomez Janette, Rosenberg Jared, Beriwal Sushil, Hyde Parker N, Champ Colin E
Department of Radiation Oncology, WellStar Paulding Medical Center, Hiram, GA.
Allegheny Health Network Cancer Institute Exercise Oncology and Resiliency Center, Pittsburgh, PA.
JCO Oncol Pract. 2025 May 7:OP2400954. doi: 10.1200/OP-24-00954.
Effective methods to improve body composition and metabolic/hormonal dysregulation are central to breast cancer care. We hypothesized that a nutrition regimen focused on food quality and an observed exercise regimen using high-load resistance training during or after cancer treatment would improve body composition and functional capacity.
Forty-four women with breast cancer, including survivors on therapy and in surveillance, excluding chemotherapy, underwent a continuously monitored dose-escalated exercise regimen utilizing heavy weights and linear progression in an exercise oncology facility along with a diet focused on food quality and adequate protein intake. Dietary strategy was discussed during each exercise session and twice monthly meetings. Pre- and post-workout assessment of body composition, functional mobility, balance, activity levels, and quality of life were compared via paired -test and Wilcoxon signed-rank test.
Forty-four women completed the protocol, with a median age of 54 years and BMI of 30.3. Most participants reported cancer-related symptoms (79.5%). Across compound exercises, composite load lifted increased by 36.5% ( < .001) and bilateral Y-balance scores increased 18% ( < .001). A 6.6% reduction in body fat was observed (1.8 kg; < .001) alongside a 1.4% increase in muscle mass (0.5 kg; = .003). Resting metabolic rate increased by 0.8% ( = .018). Significant improvements were uniformly demonstrated across quality-of-life scores (European Quality of Life 5-Dimension Score, Patient Health Questionnaire 9 Depression Scale, and Generalized Anxiety Disorder 7 questionnaires).
A 3-month regimen of nutrition counseling and high-intensity resistance training promoted significant muscle mass gain and adipose tissue loss, alongside significant improvements across body composition, strength, mobility, and functional status, and patient-reported quality of life.
改善身体成分以及代谢/激素失调的有效方法是乳腺癌护理的核心。我们假设，在癌症治疗期间或之后，以食物质量为重点的营养方案以及采用高负荷抗阻训练的观察性运动方案将改善身体成分和功能能力。
44名乳腺癌女性，包括正在接受治疗和处于监测期的幸存者（不包括化疗患者），在运动肿瘤学设施中接受了持续监测的剂量递增运动方案，该方案使用重物并采用线性进展，同时还有一个以食物质量和充足蛋白质摄入为重点的饮食方案。在每次运动课程以及每月两次的会议上讨论饮食策略。通过配对t检验和Wilcoxon符号秩检验比较锻炼前后身体成分、功能活动能力、平衡能力、活动水平和生活质量的评估结果。
44名女性完成了该方案，中位年龄为54岁，体重指数为30.3。大多数参与者报告有癌症相关症状（79.5%）。在复合运动中，举起的复合负荷增加了36.5%（P<0.001），双侧Y平衡分数增加了18%（P<0.001）。观察到体脂减少了6.6%（1.8千克；P<0.001），同时肌肉量增加了1.4%（0.5千克；P = 0.003）。静息代谢率增加了0.8%（P = 0.018）。生活质量评分（欧洲生活质量五维度评分、患者健康问卷9抑郁量表和广泛性焦虑障碍7问卷）均有显著改善。
为期3个月的营养咨询和高强度抗阻训练方案促进了显著的肌肉量增加和脂肪组织减少，同时在身体成分、力量、活动能力和功能状态以及患者报告的生活质量方面都有显著改善。
