Pace S J
Med Instrum. 1985 Jul-Aug;19(4):168-72.
Aside from the economic factors that make biosensors attractive, on-board signal conditioning and signal processing improve the limits of detection and simplify use of the devices. The present discussion summarizes the breadth of biosensor design and application, and the requirements of clinical assay detection. Current sensor research is aimed toward extending the lower limits of detection for nonradioactive immunoassays. The clinical laboratory is in a state of change; operating and instrumentation costs will affect the delivery of diagnostics. Technology will assume a major role in reshaping the clinical laboratory. Biosensors promise to deliver the diagnostic tools for the evolution that is now in progress. The clinical laboratory will no doubt continue to perform chemical profiling and the more specialized tests. The successful implementation of solid-state sensor technology promises to simplify immunoassay procedures, as the autoanalyzer did some 20 years ago for the profiling of blood metabolites. It is likely that more tests will be performed in physicians' offices with the advent of highly automated and cost-effective biosensors. By the use of this technology, practitioners of critical care medicine will be able to assume greater responsibility for diagnostic testing.
除了使生物传感器具有吸引力的经济因素外，板载信号调节和信号处理提高了检测限并简化了设备的使用。本讨论总结了生物传感器设计与应用的广度以及临床检测的要求。当前的传感器研究旨在扩展非放射性免疫测定的检测下限。临床实验室正处于变革之中；运营和仪器成本将影响诊断服务的提供。技术将在重塑临床实验室方面发挥主要作用。生物传感器有望为正在进行的发展提供诊断工具。临床实验室无疑将继续进行化学分析和更专业的检测。固态传感器技术的成功应用有望简化免疫测定程序，就像大约20年前自动分析仪对血液代谢物分析所做的那样。随着高度自动化且经济高效的生物传感器的出现，很可能会在医生办公室进行更多检测。通过使用这项技术，重症医学从业者将能够在诊断检测方面承担更大的责任。
