Hunter K W
Arch Pathol Lab Med. 1987 Jul;111(7):633-6.
The need to monitor certain key biochemical parameters in hospitalized patients is driving the development of biosensors, a new class of medical device for real-time, on-line quantitative analysis. A biosensor is a microelectronic device that utilizes a biological molecule (eg, antibody, enzyme, or receptor) as the sensing or signal-transducing element. Biosensors can be configured into simple, rapid, and cost-effective laboratory devices that will allow the clinical pathologist to become even more responsive to the primary care physician. In those instances where measurements on discrete samples do not provide the required information, continuous monitoring with implantable biosensors could provide real-time data on levels of critical endogenous or exogenous substances. By hybridizing recent advances in transdermal substance collection with the analytical capabilities of biosensors, devices for continuous noninvasive monitoring at the bedside can be envisioned. The clinical pathologist can and should play a key role in the clinical evaluation and implementation of such technological advances.
监测住院患者某些关键生化参数的需求推动了生物传感器的发展，这是一类用于实时在线定量分析的新型医疗设备。生物传感器是一种微电子设备，它利用生物分子（如抗体、酶或受体）作为传感或信号转导元件。生物传感器可以配置成简单、快速且经济高效的实验室设备，使临床病理学家能够更好地响应初级保健医生的需求。在对离散样本的测量无法提供所需信息的情况下，使用可植入生物传感器进行连续监测可以提供关键内源性或外源性物质水平的实时数据。通过将经皮物质采集的最新进展与生物传感器的分析能力相结合，可以设想出床边连续无创监测设备。临床病理学家能够且应该在这类技术进步的临床评估和实施中发挥关键作用。
