Kim Younguk, Kim Jin Hyun, Ridgel Angela L
Exercise Science and Exercise Physiology Program, Kent State University, Kent, OH, USA.
Department of Physical Medicine and Rehabilitation, The University of Alabama at Birmingham, Birmingham, AL, USA.
J Aging Phys Act. 2025 May 7:1-11. doi: 10.1123/japa.2024-0252.
Parkinson's disease (PD) affects motor and nonmotor functions, impacting PD-related quality of life. The role of physical activity (PA) in the management of PD symptoms is increasingly recognized.
To examine the effects of PA levels on PD motor and nonmotor symptoms, and health-related quality of life, using the Fox Insight study's data set. It also examines PA's moderating effects on the age-PD motor function relationship.
In this cross-sectional observational study, 1,288 participants with PD (55.8% men, age: 64.54 ± 9.99) from the Fox Insight study were divided into four groups (N = 322 each) based on their PA level as measured by the Physical Activity Scale for the Elderly (PASE). PD motor and nonmotor symptoms were assessed using the Unified Parkinson's Disease Rating Scale-2 (UPDRS-2), Parkinson's Disease Questionnaire-8 (PDQ-8), Geriatric Depression Scale-Short Form, Penn Parkinson's Daily Activities Questionnaire-15, and EuroQol-Visual Analog Scale. Statistical analyses included Kruskal-Wallis, Pearson's correlation, and multiple linear regression, with alpha set at .05.
Higher PASE correlated with better UPDRS-2, Parkinson's Disease Questionnaire-8, Geriatric Depression Scale-Short Form, Penn Parkinson's Daily Activities Questionnaire-15, and EuroQol-Visual Analog Scale. The study found significant influences of PASE on UPDRS-2, age, Geriatric Depression Scale-Short Form, body mass index, and EQ-VAS (R2adj = .174, F = 53.998, p < .001). Notably, PASE moderated the relationship between age and UPDRS-2, suggesting a pivoting role in slowing PD-related symptom progression with age (R2adj = .145, F = 73.47, p < .001).
Increased PA levels are associated with better outcomes in PD motor and nonmotor symptoms, improved PD-related quality of life, and a slowed progression of PD symptoms.
Promoting higher levels of PA in older adults with PD effectively manages motor and nonmotor symptoms of PD. In addition, early and consistent PA is the key to moderating the progression of PD symptoms.
帕金森病（PD）会影响运动和非运动功能，进而影响与PD相关的生活质量。体育活动（PA）在PD症状管理中的作用日益受到认可。
利用Fox Insight研究的数据集，研究PA水平对PD运动和非运动症状以及与健康相关的生活质量的影响。它还研究了PA对年龄与PD运动功能关系的调节作用。
在这项横断面观察性研究中，来自Fox Insight研究的1288名PD患者（男性占55.8%，年龄：64.54±9.99）根据其通过老年人体育活动量表（PASE）测量的PA水平分为四组（每组N = 322）。使用统一帕金森病评定量表-2（UPDRS-2）、帕金森病问卷-8（PDQ-8）、老年抑郁量表简版、宾夕法尼亚帕金森日常活动问卷-15和欧洲生活质量视觉模拟量表评估PD运动和非运动症状。统计分析包括Kruskal-Wallis检验、Pearson相关性分析和多元线性回归，设定α为0.05。
较高的PASE与更好的UPDRS-2、帕金森病问卷-8、老年抑郁量表简版、宾夕法尼亚帕金森日常活动问卷-15和欧洲生活质量视觉模拟量表相关。研究发现PASE对UPDRS-2、年龄、老年抑郁量表简版、体重指数和EQ-VAS有显著影响（调整后R2 = 0.174，F = 53.998，p < 0.001）。值得注意的是，PASE调节了年龄与UPDRS-2之间的关系，表明在减缓PD相关症状随年龄进展方面起关键作用（调整后R2 = 0.145，F = 73.47，p < 0.001）。
PA水平的提高与PD运动和非运动症状的更好结果、PD相关生活质量的改善以及PD症状进展的减缓相关。
在老年PD患者中促进更高水平的PA可有效管理PD的运动和非运动症状。此外，早期和持续的PA是减缓PD症状进展的关键。
