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COVID-19大流行对日本大都市队列中老年人新长期护理保险申请和全因死亡率的影响:一项中断时间序列分析

Impact of the COVID-19 Pandemic on New Long-term Care Insurance Applications and All-Cause Mortality in Older Adults in a Japanese Metropolitan Cohort: An Interrupted Time-Series Analysis.

作者信息

Seino Satoshi, Hata Toshiki, Mori Hiroki, Shinkai Shoji, Fujiwara Yoshinori, Kobayashi Erika

机构信息

Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology.

Institute of Well-Being, Yamagata University.

出版信息

J Epidemiol. 2025 May 3. doi: 10.2188/jea.JE20240464.

Abstract

PURPOSE

New long-term care insurance (LTCI) certifications and mortality are key outcomes in cohort studies involving older adults; however, the coronavirus disease 2019 (COVID-19)'s comprehensive impacts on these outcomes remain underexplored. We examined the pandemic's impact on new LTCI applications and all-cause mortality in a metropolitan cohort.

METHODS

In 2016, 15,500 individuals aged 65-84 years were randomly selected through stratified sampling from Ota City, Tokyo. LTCI and death records were tracked through December 2023; the monthly LTCI applications and all-cause deaths per 10,000 people were calculated. The COVID-19 pandemic period was defined as beginning in March 2020, after the World Health Organization Director-General characterized the situation as a pandemic on March 11, 2020. Interrupted time-series segmented regression analysis was used to compare trends pre- (January 2018-February 2020) and post-pandemic onset (March 2020-December 2023).

RESULTS

From January 2018 to December 2023, 4083 new LTCI applications and 2457 deaths were recorded. New monthly LTCI applications showed a modest upward trend pre-pandemic (0.4 per 10,000 people, 95% confidence interval [CI]: 0.1-0.8), declined sharply at the pandemic's onset (-9.6 per 10,000 people, 95% CI: -16.0 to -3.2), and subsequently increased at a higher rate than pre-pandemic levels (0.8 per 10,000 people, 95% CI: 0.6-1.0). Monthly all-cause deaths remained stable before and immediately after the pandemic's onset but rose slightly in the post-pandemic period (0.3 per 10,000 people per month, 95% CI: 0.2-0.5).

CONCLUSIONS

The COVID-19 pandemic influenced both new LTCI applications and all-cause mortality in this study. These impacts should be carefully considered in cohort studies examining these outcomes.

摘要

目的

新的长期护理保险(LTCI)认证和死亡率是涉及老年人的队列研究中的关键结果;然而,2019年冠状病毒病(COVID-19)对这些结果的全面影响仍未得到充分探索。我们研究了疫情对一个大都市队列中新的LTCI申请和全因死亡率的影响。

方法

2016年,通过分层抽样从东京大田市随机选取了15500名65 - 84岁的个体。追踪LTCI和死亡记录至2023年12月;计算每月每10000人中的LTCI申请数和全因死亡数。COVID-19大流行期定义为从2020年3月开始,即世界卫生组织总干事于2020年3月11日将该情况定性为大流行之后。采用中断时间序列分段回归分析来比较大流行前(2018年1月 - 2020年2月)和大流行开始后(2020年3月 - 2023年12月)的趋势。

结果

从2018年1月到2023年12月,记录了4083份新的LTCI申请和2457例死亡。每月新的LTCI申请在大流行前呈适度上升趋势(每10000人中有0.4份,95%置信区间[CI]:0.1 - 0.8),在大流行开始时急剧下降(每10000人中有 - 9.6份,95% CI: - 16.0至 - 3.2),随后以高于大流行前水平的速率增加(每10000人中有0.8份,95% CI:0.6 - 1.0)。每月全因死亡数在大流行开始前后保持稳定,但在大流行后时期略有上升(每月每10000人中有0.3例,95% CI:0.2 - 0.5)。

结论

在本研究中,COVID-19大流行影响了新的LTCI申请和全因死亡率。在研究这些结果的队列研究中应仔细考虑这些影响。

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