以脊髓髓内转移为乳腺癌首发表现：病例报告及文献复习
Intramedullary spinal cord metastasis presenting as the initial manifestation of breast cancer: case report and review of the literature.
作者信息
Bouattour Nadia, Sellami Sirine, Mzid Yosra, Charfi Slim, Hamza Fatma, Sakka Salma, Ben Mahfoudh Khaireddine, Bahloul Amine, Damak Mariem
机构信息
Department of Neurology and Research Laboratory LR12SP19, Habib Bourguiba University Hospital, Sfax, Tunisia.
Medical School of Sfax, University of Sfax, Sfax, Tunisia.
出版信息
Spinal Cord Ser Cases. 2025 May 7;11(1):13. doi: 10.1038/s41394-025-00708-y.
BACKGROUND
Intramedullary spinal cord metastasis (ISCM) is very rare. Symptoms from ISCM metastasis being the initial presentation are extremely rare.
CASE PRESENTATION
We present a case of a 42-year-old woman without previous medical history who presented with complaints of progressive lower limb weakness of three weeks evolution. Neurological examination elicited a medullary syndrome, and physical examination showed a palpable mass on her right breast. A spinal MRI revealed a dorsal intramedullary tumor mass. A biopsy sample from the breast mass revealed the diagnosis of carcinoma. The diagnosis of an Intramedullary breast cancer metastasis (IMBCM) was made according to positron emission tomography. The patient received treatment with corticosteroids and radiation therapy without improvement, and she died, 3 months after the diagnosis.
CONCLUSIONS
As far as we know, this is the first reported case of IMBCM revealing a breast carcinoma. Although extremely rare, ISCM should be considered as a differential diagnosis of a spinal intramedullary lesion.
背景
脊髓髓内转移瘤（ISCM）非常罕见。以ISCM转移症状为首发表现极为罕见。
病例报告
我们报告一例42岁女性，既往无病史，主诉进行性下肢无力3周。神经系统检查引出延髓综合征，体格检查发现右乳可触及肿块。脊柱MRI显示脊髓背侧肿瘤肿块。乳腺肿块活检样本确诊为癌。根据正电子发射断层扫描诊断为髓内乳腺癌转移（IMBCM）。患者接受皮质类固醇和放射治疗后无改善，诊断后3个月死亡。
结论
据我们所知，这是首例报告的IMBCM显示乳腺癌的病例。尽管ISCM极为罕见，但应将其视为脊髓髓内病变的鉴别诊断。
Zotero 插件