Takahashi Yugo, Wang Qingbo S, Hasegawa Takanori, Namkoong Ho, Inoue Fumitaka, Fukunaga Koichi, Imoto Seiya, Miyano Satoru, Okada Yukinori
Faculty of Medicine, Osaka University, Suita, Japan.
Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan.
BMC Genomics. 2025 May 7;26(1):451. doi: 10.1186/s12864-025-11639-1.
We present the Japan Omics Browser (JOB), which enables integrative analysis of human omics at different layers. JOB offers visualization of per-variant regulatory effects in the human blood at mRNA and protein level distinctively, quantified from statistical fine-mapping of mRNA-expression quantitative loci (eQTL) and protein QTLs (pQTLs) in 1,405 Japanese, together with fine-mapping results of 94 complex traits in UK Biobank. In addition, JOB shows per-tissue regulatory effect prediction score (EMS), trained via multi-task learning. Furthermore, validation scores from Massively Parallel Reporter Assay (MPRA) in two cell types are available for over 10,000 variants. JOB is publicly available at https://japan-omics.jp/ .
我们展示了日本组学浏览器（JOB），它能够对不同层面的人类组学进行综合分析。JOB特别提供了在mRNA和蛋白质水平上人类血液中每个变异体调控效应的可视化，这些效应是通过对1405名日本人的mRNA表达定量位点（eQTL）和蛋白质QTL（pQTL）进行统计精细定位量化得到的，同时还展示了英国生物银行中94种复杂性状的精细定位结果。此外，JOB还展示了通过多任务学习训练得到的每个组织的调控效应预测分数（EMS）。此外，超过10000个变异体在两种细胞类型中的大规模平行报告基因检测（MPRA）验证分数也可获取。JOB可在https://japan-omics.jp/ 上公开获取。
