Shanady Nora M Abo, Abo Hamila Nahed A, El Maghraby Gamal M, Ghouraba Rehab F
Pediatric Dentistry, Preventive Dentistry Department, Faculty of Dentistry, Oral Health, Tanta University, Tanta, 31111, Egypt.
Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, Egypt.
BMC Oral Health. 2025 May 7;25(1):692. doi: 10.1186/s12903-025-05997-1.
The concept of vital pulp therapy (VPT) of immature permanent teeth has evolved in recent years. There has been a great tendency towards investigating new pulp capping materials for perfect imitation for natural dentin-pulp complex formation process and restoring the normal tissue's characteristics. Therefore, this study aimed to assess the clinical and tomographic outcomes of apexogenesis with human treated dentin matrix (hTDM) compared to mineral trioxide aggregate (MTA).
40 bilateral deep carious young mandibular first permanent molars (FPMs) in 20 healthy children aged between 6 and 8 years old were randomly allocated into 2 groups in which the FPMs treated with hTDM and MTA after pulpotomy procedure. The children were followed up clinically at 3, 6, 12, and 18 months. Tomographic evaluation was performed at baseline and 18-month evaluation period.
The overall clinical success rate was 100% in both groups. Regarding tomographic evaluation, the mean differences in root length, periapical diameter and area were statistically significant in each individual group but without statistically significant differences between both groups.
Human TDM hydrogel could be considered a promising pulpotomy agent for immature permanent teeth.
The current clinical trial was recorded at clinicaltrials.gov, NCT06116695, 27/10/2023, Retrospectively registered.
近年来，未成熟恒牙的活髓治疗（VPT）概念不断发展。人们一直倾向于研究新的牙髓盖髓材料，以完美模拟天然牙本质-牙髓复合体的形成过程并恢复正常组织的特性。因此，本研究旨在评估与三氧化矿物凝聚体（MTA）相比，用人处理过的牙本质基质（hTDM）进行根尖诱导成形术的临床和断层扫描结果。
将20名6至8岁健康儿童的40颗双侧深龋下颌第一恒磨牙（FPM）随机分为2组，在牙髓切断术后分别用hTDM和MTA治疗这些FPM。在3、6、12和18个月时对儿童进行临床随访。在基线和18个月评估期进行断层扫描评估。
两组的总体临床成功率均为100%。关于断层扫描评估，每组牙根长度、根尖直径和面积的平均差异在统计学上具有显著性，但两组之间无统计学显著差异。
人TDM水凝胶可被认为是一种有前途的未成熟恒牙牙髓切断术用药。
当前临床试验已在clinicaltrials.gov上记录，NCT06116695，2023年10月27日，回顾性注册。
