Fukaya H, Koyama K, Ouchi K, Sato T
Nihon Geka Gakkai Zasshi. 1985 Jun;86(6):709-16.
Cross-circulation was performed to investigate the mitochondrial respiratory function of the liver and kidney in rats after 1, 2 and 3 weeks of biliary obstruction. Serum bilirubin and total bile acids concentration in blood in rats with biliary obstruction markedly decreased with 3 hours cross-circulation. There demonstrated, however, no significant change in mitochondrial function in the liver after cross-circulation. In contrast, mitochondrial function in the kidney showed significant improvement after 3 hours cross-circulation. Mitochondrial respiratory function in normal partner rats cross-circulation with jaundiced rats demonstrated temporal deterioration in the kidney and prolonged deterioration in the liver. It can be concluded that cross-circulation or plasma exchange might be useful for the prevention of renal failure in obstructive jaundice, since cross-circulation induced persistent improvement of the mitochondrial respiratory function in the kidney deteriorated by biliary obstruction.
进行交叉循环以研究大鼠胆道梗阻1、2和3周后肝脏和肾脏的线粒体呼吸功能。胆道梗阻大鼠交叉循环3小时后，血液中的血清胆红素和总胆汁酸浓度显著降低。然而，交叉循环后肝脏的线粒体功能没有显著变化。相比之下，交叉循环3小时后肾脏的线粒体功能有显著改善。正常对照大鼠与黄疸大鼠交叉循环后，肾脏的线粒体呼吸功能出现暂时恶化，而肝脏的线粒体呼吸功能则出现持续恶化。可以得出结论，交叉循环或血浆置换可能有助于预防梗阻性黄疸中的肾衰竭，因为交叉循环可使因胆道梗阻而受损的肾脏线粒体呼吸功能持续改善。
