Koyama K, Asanuma Y, Fukaya H, Omokawa S
Department of Surgery, Akita University School of Medicine, Japan.
Artif Organs. 1988 Aug;12(4):305-9. doi: 10.1111/j.1525-1594.1988.tb02778.x.
This paper is aimed at evaluating the effect of blood purification on the mitochondrial functions of the kidney in jaundiced rats. At 1, 2, or 3 weeks after bile duct ligation and dissection, obstructive jaundiced rats were utilized for experiment. Cross circulation in 1 ml/min between jaundiced rats and normal rats was performed for 1 or 3 h. Immediately and 24 h after cross circulation, the rats were killed and mitochondrial respiratory functions of the kidney were assessed by measuring oxygen consumption. Mitochondrial function, especially ATP synthesis, showed significant improvement in jaundiced rat with 2 or 3 weeks of biliary obstruction. Cross circulation for 3 h was more effective than that for 1 h. These data suggest that the renal energy production can be increased significantly in obstructive jaundice by blood purification treatment.
本文旨在评估血液净化对黄疸大鼠肾脏线粒体功能的影响。在胆管结扎和解剖后1、2或3周，将梗阻性黄疸大鼠用于实验。在黄疸大鼠和正常大鼠之间以1 ml/min的速度进行交叉循环1或3小时。交叉循环后立即和24小时后，处死大鼠并通过测量氧气消耗来评估肾脏的线粒体呼吸功能。线粒体功能，尤其是ATP合成，在梗阻性黄疸2或3周的大鼠中显示出显著改善。3小时的交叉循环比1小时的更有效。这些数据表明，通过血液净化治疗可显著增加梗阻性黄疸时的肾脏能量产生。
