Hoshino S, Nonami T
Nihon Geka Gakkai Zasshi. 1985 Jun;86(6):738-51.
This study was undertaken in order to clarify the influence of acute portal vein occlusion (PVO) and the following restoration of portal vein flow (R-PVF) in adult mongrel dogs. Acute abnormality was observed on systemic circulation and oxygen metabolism quickly after PVO, causing the shock to dogs. The hypovolemia causing by splanchnic sequestration was the leading cause at the early stage. As the occlusion time was extended, the cardiac function was lowered and the oxygen metabolism was destroyed. Using Anthron bypass catheter between portal and femoral veins during the PVO, the intestinal blood congestion was prevented and the influence on the oxygen metabolism was slight. After R-PVF, the cardiac functional deterioration and deficient compensation of oxygen metabolism were observed, which were more worsened as the occlusion time was longer. The simultaneous occlusion of the portal vein and superior mesenteric artery failed to improve the deterioration of systemic circulation and oxygen metabolism. No improvement of prognosis of dogs was found either. On the contrary, the systemic circulation was improved through the administration of dobutamine during PVO and after R-PVF, the improvement of systemic circulation and oxygen metabolism was also improved and the prognosis of dogs was improved.
本研究旨在阐明成年杂种犬急性门静脉闭塞（PVO）及随后门静脉血流恢复（R-PVF）的影响。PVO后很快在体循环和氧代谢方面观察到急性异常，导致犬休克。早期内脏隔离引起的血容量减少是主要原因。随着闭塞时间延长，心脏功能降低，氧代谢遭到破坏。在PVO期间使用门静脉与股静脉之间的Anthron旁路导管，可防止肠淤血，对氧代谢的影响轻微。R-PVF后，观察到心脏功能恶化和氧代谢代偿不足，且随着闭塞时间延长情况更糟。同时闭塞门静脉和肠系膜上动脉未能改善体循环和氧代谢的恶化。犬的预后也未改善。相反，在PVO期间给予多巴酚丁胺可改善体循环，R-PVF后体循环和氧代谢的改善也得以提升，犬的预后得到改善。
