Miyakawa S
Nihon Geka Gakkai Zasshi. 1984 Jul;85(7):719-28.
The effect of portal vein occlusion (PVO) on the mesenteric microcirculation was studied with light microscope and electronmicroscope in the following three groups of mongrel dogs; the first group consisted of 3 dogs with laparotomy only, the second consisted of 10 dogs with PVO and the third consisted of 10 dogs with PVO and porto-femoral vein bypass using the antithrombogenic catheter (Anthron bypass tube). In the second group, dilatation of venula and slow blood flow in venula, patent A-V shunt and stasis in the capillary network were seen after 15 minutes. Hemorrhage and stasis in venula were observed after 15-30 minutes. Sludging and stasis in arteriole were also observed after 45-60 minutes. The hemorrhage of venula was progressive. Electronmicroscopically the vascular endothelial cell began to show abnormality after 15-30 minutes, and the microvilli of small intestinal mucosa showed pathological changes after 30 minutes. In the third group, the disturbance of the mesenteric microcirculation was mild even 4 hours after PVO. Both vascular endothelial cell and microbilli of the small intestinal mucosa were not damaged. We concluded that PVO causes the pathological changes of mesenteric microcirculation and intestinal mucosa at an early stage and the porto-femoral vein bypass using the antithrombogenic catheter is a safe and useful procedure when PVO is needed.
采用光镜和电镜研究了门静脉闭塞（PVO）对三组杂种犬肠系膜微循环的影响。第一组为3只仅行剖腹术的犬，第二组为10只接受PVO的犬，第三组为10只接受PVO并使用抗血栓形成导管（Anthron分流管）进行门静脉-股静脉分流的犬。第二组在15分钟后可见微静脉扩张、微静脉内血流缓慢、动静脉分流开放及毛细血管网内血流淤滞。15 - 30分钟后观察到微静脉出血和淤滞。45 - 60分钟后还观察到小动脉内血细胞淤滞和血流淤滞。微静脉出血呈进行性。电镜下，15 - 30分钟后血管内皮细胞开始出现异常，30分钟后小肠黏膜微绒毛出现病理变化。第三组即使在PVO后4小时，肠系膜微循环的紊乱也很轻微。血管内皮细胞和小肠黏膜微绒毛均未受损。我们得出结论，PVO在早期会引起肠系膜微循环和肠黏膜的病理变化，当需要进行PVO时，使用抗血栓形成导管进行门静脉-股静脉分流是一种安全有效的方法。
