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非动脉炎性急性缺血性视神经病变中的结构-功能相关性

Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy.

作者信息

Wei Junhan, Zhang Lei, Wang Haiyan, Wang Qianfeng, Jia Wei, Wang Ru, Wang Runsheng, Cui Zhili

机构信息

Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, People's Republic of China; Xi'an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi'an, 710004, People's Republic of China.

Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People's Republic of China.

出版信息

Eye Brain. 2025 May 3;17:13-25. doi: 10.2147/EB.S512882. eCollection 2025.

DOI:10.2147/EB.S512882
PMID:40336777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12057633/
Abstract

PURPOSE

This study investigated the relationships between structural and functional parameters in non-arteritic ischemic optic neuropathy (NAION).

METHODS

This retrospective study enrolled 29 patients (58.2 ± 10.4 years old) with unilateral NAION. During the acute phase, we performed comprehensive evaluations including best-corrected visual acuity (BCVA), optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), visual fields (VF), visual evoked potentials (VEP), electroretinography (ERG), and multifocal ERG (mf-ERG). At three months post-presentation, patients underwent follow-up assessments comprising visual acuity testing, perimetry, and advanced retinal imaging.

RESULTS

During the acute phase, affected eyes demonstrated increased mean retinal nerve fiber layer (RNFL) thickness, while ganglion cell-inner plexiform layer (GCIPL) thickness decreased. Both visual fields mean deviation (MD) and VEP P100 amplitude were reduced, accompanied by prolonged peak latency. We also observed decreased P1 response density in mf-ERG. Analysis revealed significant direct correlations between GCIPL parameters and electrophysiological measurements, particularly VEP P100 amplitude and mf-ERG P1 response density. Mean GCIPL thickness, VF MD, and VEP P100 amplitude showed negative correlations with baseline logMAR VA. Baseline VF MD, VEP P100 amplitude, and minimum GCIPL thickness showed negative correlations with logMAR VA at 3-month follow-up.

CONCLUSION

Retinal ganglion cell layer thickness serves as a valuable indicator to objective evaluate optic nerve function in acute NAION patients. Decreases in both VEP amplitude and mf-ERG response density showed significant correlations with retinal ganglion cell layer thickness. Baseline visual field performance, VEP measurements, and minimum GCIPL thickness exhibited negative correlations visual acuity at 3-month follow-up.

TRIAL REGISTRATION

Clinical Research Ethics Committee of Xi'an People's Hospital (NO. 20220018). Registered 27 September 2022-Retrospectively registered, https://www.medicalresearch.org.cn/. Informed consent was obtained from each participant.

摘要

目的

本研究调查了非动脉炎性缺血性视神经病变（NAION）的结构和功能参数之间的关系。

方法

这项回顾性研究纳入了29例单侧NAION患者（年龄58.2±10.4岁）。在急性期，我们进行了全面评估，包括最佳矫正视力（BCVA）、光学相干断层扫描（OCT）、光学相干断层扫描血管造影（OCTA）、视野（VF）、视觉诱发电位（VEP）、视网膜电图（ERG）和多焦视网膜电图（mf-ERG）。在就诊后三个月，患者接受了包括视力测试、视野检查和高级视网膜成像的随访评估。

结果

在急性期，患眼平均视网膜神经纤维层（RNFL）厚度增加，而神经节细胞-内丛状层（GCIPL）厚度减少。视野平均偏差（MD）和VEP P100振幅均降低，同时峰值潜伏期延长。我们还观察到mf-ERG中P1反应密度降低。分析显示GCIPL参数与电生理测量之间存在显著的直接相关性，特别是VEP P100振幅和mf-ERG P1反应密度。平均GCIPL厚度、VF MD和VEP P100振幅与基线logMAR视力呈负相关。基线VF MD、VEP P100振幅和最小GCIPL厚度与随访3个月时的logMAR视力呈负相关。

结论

视网膜神经节细胞层厚度是客观评估急性NAION患者视神经功能的有价值指标。VEP振幅和mf-ERG反应密度的降低与视网膜神经节细胞层厚度显著相关。基线视野表现、VEP测量和最小GCIPL厚度与随访3个月时的视力呈负相关。

试验注册

西安市人民医院临床研究伦理委员会（编号20220018）。2022年9月27日注册——回顾性注册，https://www.medicalresearch.org.cn/。已获得每位参与者的知情同意。

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本文引用的文献

1
The current clinical role of optical coherence tomography angiography in neuro-ophthalmological diseases.光学相干断层扫描血管造影在神经眼科疾病中的当前临床作用。
Taiwan J Ophthalmol. 2022 Feb 11;12(3):264-272. doi: 10.4103/tjo.tjo_55_21. eCollection 2022 Jul-Sep.
2
The relation of the multifocal electroretinographic response to macular layer volume.多焦视网膜电图反应与黄斑层容积的关系。
Doc Ophthalmol. 2022 Aug;145(1):1-10. doi: 10.1007/s10633-022-09873-z. Epub 2022 May 10.
3
ISCEV Standard for full-field clinical electroretinography (2022 update).
国际临床电生理学会标准：全视野临床视网膜电流图（2022 更新版）。
Doc Ophthalmol. 2022 Jun;144(3):165-177. doi: 10.1007/s10633-022-09872-0. Epub 2022 May 5.
4
Introduction to the special section on Visual electrophysiology 2021: a coming of age.2021年视觉电生理学专题介绍：走向成熟。
Eye (Lond). 2021 Sep;35(9):2339-2340. doi: 10.1038/s41433-021-01678-9. Epub 2021 Jul 16.
5
Structure-Function Relationship of Retinal Ganglion Cells in Multiple Sclerosis.多发性硬化症中视网膜神经节细胞的结构-功能关系。
Int J Mol Sci. 2021 Mar 26;22(7):3419. doi: 10.3390/ijms22073419.
6
ISCEV standard for clinical multifocal electroretinography (mfERG) (2021 update).国际临床多焦视网膜电图学会标准（2021 年更新版）。
Doc Ophthalmol. 2021 Feb;142(1):5-16. doi: 10.1007/s10633-020-09812-w. Epub 2021 Jan 25.
7
Peripapillary and Macular Flow Changes in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) by Optical Coherence Tomography Angiography (OCT-A).光学相干断层扫描血管造影（OCT-A）评估非动脉炎性前部缺血性视神经病变（NAION）中视乳头周围和黄斑区血流变化
J Ophthalmol. 2020 Nov 2;2020:3010631. doi: 10.1155/2020/3010631. eCollection 2020.
8
Correlations between visual morphological, electrophysiological, and acuity changes in chronic non-arteritic ischemic optic neuropathy.慢性非动脉炎性前部缺血性视神经病变的视觉形态、电生理和视力变化之间的相关性。
Graefes Arch Clin Exp Ophthalmol. 2021 May;259(5):1297-1308. doi: 10.1007/s00417-020-05023-w. Epub 2021 Jan 7.
9
Optical Coherence Tomography Angiography Assessment of the Peripapillary Vessel Density and Structure in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy: A Meta-Analysis.光学相干断层扫描血管造影评估非动脉炎性前部缺血性视神经病变患者的视盘周围血管密度和结构：一项荟萃分析。
Biomed Res Int. 2020 Oct 29;2020:1359120. doi: 10.1155/2020/1359120. eCollection 2020.
10
Optical coherence tomography angiography in neuro-ophthalmology: Current clinical role and future perspectives.神经眼科中的光相干断层扫描血管造影：当前的临床作用和未来展望。
Surv Ophthalmol. 2021 May-Jun;66(3):471-481. doi: 10.1016/j.survophthal.2020.10.009. Epub 2020 Nov 3.