Bhatta Rohit, Irrinki Santosh, Gupta Vikas, Yadav Thakur Deen, Sakaray Yashwant Raj, Kumar Hemanth, Nada Ritambhra, Singh Harjeet
Department of Surgical Gastroenterology, Nehru Hospital, Post Graduate Institute of Medical Education and Research, F-block, Sector 12, Chandigarh, India.
Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Surg Oncol. 2025 Apr;16(2):502-507. doi: 10.1007/s13193-023-01805-w. Epub 2023 Aug 21.
Solid pseudopapillary neoplasm (SPN) is uncommon and constitutes to 1-2% of pancreatic tumours. Owing to its rarity, literature is sparse on its clinicopathological characteristics and surgical outcomes. Our study is a retrospective analysis of prospectively maintained data of patients with histologically proven SPN between January 2012 and December 2019. Patients' demography, clinical presentation, preoperative imaging, operative details, perioperative outcomes, and long-term follow-up were recorded and analyzed. A total of 14 patients were included in the study, all were females with a median age of 19.5 years (range 15-35 years). All presented with pain abdomen. Eight (57.1%) out of 14 patients were correctly diagnosed with contrast-enhanced computed tomography (CECT) abdomen. CECT revealed solid cystic well-encapsulated lesions in 12(85.7%) and homogenous mass lesions without cystic changes in 2 (14.2%) patients. The most common tumour location was head/uncinate process (57.1%). Eight (57.1%) underwent pancreaticoduodenectomy and 6 (42.8%) had undergone distal pancreatectomy. The median size of tumour was 10 cm (4.5-14 cm). The median postoperative stay was 9 days (range 4-20 days). Seven patients (50%) developed postoperative pancreatic fistula (Grade-A-6/7, Grade-B-1/7) and delayed gastric emptying (DGE) was noted in two (14.2%). R0 resection could be achieved in 13 patients (92.8%). Median follow-up period was 49.5 months. One patient had postoperative recurrence after 48 months of surgery. SPN is a rare tumour of pancreas. Surgical resection is associated with acceptable morbidity and is required for potential cure.
实性假乳头状肿瘤（SPN）并不常见，占胰腺肿瘤的1%-2%。由于其罕见性，关于其临床病理特征和手术结果的文献较少。我们的研究是对2012年1月至2019年12月间组织学确诊为SPN的患者的前瞻性维护数据进行回顾性分析。记录并分析了患者的人口统计学资料、临床表现、术前影像学检查、手术细节、围手术期结果和长期随访情况。该研究共纳入14例患者，均为女性，中位年龄19.5岁（范围15-35岁）。所有患者均表现为腹痛。14例患者中有8例（57.1%）通过腹部增强计算机断层扫描（CECT）得到正确诊断。CECT显示12例（85.7%）为实性囊性且边界清晰的病变，2例（14.2%）为无囊性改变的均匀肿块病变。最常见的肿瘤部位是胰头/钩突（57.1%）。8例（57.1%）患者接受了胰十二指肠切除术，6例（42.8%）接受了胰体尾切除术。肿瘤的中位大小为10 cm（4.5-14 cm）。术后中位住院时间为9天（范围4-20天）。7例患者（50%）发生了术后胰瘘（A级6/7例，B级1/7例），2例（14.2%）出现了胃排空延迟（DGE）。13例患者（92.8%）实现了R0切除。中位随访期为49.5个月。1例患者在手术后48个月出现术后复发。SPN是一种罕见的胰腺肿瘤。手术切除的发病率可接受，是实现潜在治愈所必需的。
