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放射性皮炎防治中国临床实践指南

Chinese clinical practice guidelines for the prevention and treatment of radiation-induced dermatitis.

作者信息

Fan Ming, Feng Mei, Yuan Shuanghu

机构信息

China Anti-Cancer Association Tumor Support Therapy Committee.

China Anti-Cancer Association Tumor Radiation Protection Committee.

出版信息

Precis Radiat Oncol. 2023 Sep 10;7(3):160-172. doi: 10.1002/pro6.1208. eCollection 2023 Sep.

DOI:10.1002/pro6.1208
PMID:40337200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11935096/
Abstract

Radiation-induced dermatitis is one of the most prevalent complications in patients undergoing cancer radiotherapy and poses a significant challenge to cancer therapy. The symptoms include erythema, dry desquamation, and moist desquamation, which are frequently observed in patients with breast, head and neck, anal, and vulvar cancers. Early skin reactions typically manifest within 2-4 weeks following the initiation of radiotherapy. In severe cases, acute dermatitis can cause radiotherapy interruptions, prolong treatment time, and ultimately affect patient outcomes and quality of life. Currently, there are numerous guidelines on radiation dermatitis, including the Multinational Association of Supportive Care in Cancer (MASCC), British Columbia Cancer Agency (BCCA), Oncology Nursing Society (ONS), and UK Society of Radiographers (SCoR) guidelines. In China, dermatology experts have drafted a consensus. However, due to the differing backgrounds of experts, recommendations among guidelines vary. These guidelines were first developed by Chinese radiation oncologists. The evidence-based guideline in this paper fully considers and adopts China's national conditions; hence, it can be easily applied in daily practice.

摘要

放射性皮炎是癌症放疗患者中最常见的并发症之一,对癌症治疗构成重大挑战。症状包括红斑、干性脱屑和湿性脱屑,在乳腺癌、头颈癌、肛门癌和外阴癌患者中经常出现。早期皮肤反应通常在放疗开始后的2 - 4周内出现。在严重情况下,急性皮炎会导致放疗中断、延长治疗时间,并最终影响患者的治疗效果和生活质量。目前,关于放射性皮炎有许多指南,包括癌症支持治疗多国协会(MASCC)、不列颠哥伦比亚癌症机构(BCCA)、肿瘤护理学会(ONS)和英国放射技师协会(SCoR)的指南。在中国,皮肤科专家已经起草了一项共识。然而,由于专家背景不同,各指南之间的建议存在差异。这些指南最初是由中国放射肿瘤学家制定的。本文基于循证的指南充分考虑并采用了中国国情,因此可以很容易地应用于日常实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07d/11935096/bb72ca441304/PRO6-7-160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07d/11935096/02b69fc7d87b/PRO6-7-160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07d/11935096/bb72ca441304/PRO6-7-160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07d/11935096/02b69fc7d87b/PRO6-7-160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07d/11935096/bb72ca441304/PRO6-7-160-g001.jpg

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本文引用的文献

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The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study.重组人表皮生长因子对直肠癌和肛门癌患者放射性皮炎的影响:一项自身对照研究。
BMC Cancer. 2022 Nov 5;22(1):1140. doi: 10.1186/s12885-022-10226-x.
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Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts.用于加速活动部位伤口修复的机械活性纳米复合水凝胶
ACS Nano. 2022 Dec 27;16(12):20044-20056. doi: 10.1021/acsnano.2c07483. Epub 2022 Oct 27.
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Radiation recall dermatitis induced by COVID-19 vaccination in breast cancer patients treated with postoperative radiation therapy.
接受术后放疗的乳腺癌患者接种 COVID-19 疫苗后引发的放射性回忆性皮炎。
Breast. 2022 Oct;65:49-54. doi: 10.1016/j.breast.2022.06.008. Epub 2022 Jul 2.
4
Radiation recall dermatitis: A review of the literature.放射性回忆性皮炎:文献复习。
Semin Oncol. 2022 Apr;49(2):152-159. doi: 10.1053/j.seminoncol.2022.04.001. Epub 2022 Apr 29.
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Scalp-Sparing Radiation With Concurrent Temozolomide and Tumor Treating Fields (SPARE) for Patients With Newly Diagnosed Glioblastoma.同步替莫唑胺和肿瘤治疗电场的保留头皮放疗(SPARE)用于新诊断的胶质母细胞瘤患者。
Front Oncol. 2022 Apr 29;12:896246. doi: 10.3389/fonc.2022.896246. eCollection 2022.
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[Prognostic factors of acute radiodermatitis in breast cancer after adjuvant radiotherapy treated with RT3D or IMRT].[三维适形放疗(RT3D)或调强放疗(IMRT)辅助放疗后乳腺癌急性放射性皮炎的预后因素]
Cancer Radiother. 2022 Sep;26(5):684-691. doi: 10.1016/j.canrad.2021.12.004. Epub 2022 Feb 25.
7
Comparison of clinical practice guidelines on radiation dermatitis: a narrative review.比较辐射性皮炎临床实践指南:叙述性综述。
Support Care Cancer. 2022 Jun;30(6):4663-4674. doi: 10.1007/s00520-022-06829-6. Epub 2022 Jan 24.
8
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Radiat Oncol J. 2021 Dec;39(4):315-323. doi: 10.3857/roj.2020.00395. Epub 2021 Dec 24.
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