Duvančić Tea, Vukasović Barišić Andreja, Plečko Mihovil, Čizmić Ana, Bohaček Ivan, Delimar Domagoj
Department of Orthopaedic Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia.
University Hospital Bjelovar, Bjelovar, Croatia.
Acta Clin Croat. 2023 Aug;62(Suppl3):30-36. doi: 10.20471/acc.2023.62.s3.4.
The aim of our study was to compare acetabular cartilage affected by primary and DDH-induced secondary osteoarthritis (OA) using T2 mapping, which gives us information about cartilage water and collagen content, and the orientation of collagen fibrils. Samples of the osteochondral unit were obtained intraoperatively during total hip arthroplasty from the acetabulum of 15 patients with primary OA (pOA-Ac) and 15 patients with DDH-induced secondary OA (sOA-Ac). The samples were then scanned on a 7 Tesla micro-magnetic resonance imaging (micro-MRI) machine and the T2 values of all samples were calculated. The results were compared using a t-test. The average T2 values for the sOA-Ac and pOA-Ac groups were 57.28±31.87 ms and 37.54±11.17 ms, respectively. The calculated p-value was 0.019, making results statistically significant at p<0.5. This is one of the first studies performed ex vivo on the acetabular cartilage of human dysplastic hips, using a 7 Tesla MRI machine. Our results show that acetabular cartilage in DDH-induced secondary OA is more damaged than in primary OA, and offer 7 Tesla T2 reference values of acetabular cartilage for both the primary and DDH-induced secondary OA.
我们研究的目的是使用T2成像技术比较原发性骨关节炎（OA）和发育性髋关节发育不良（DDH）所致继发性骨关节炎影响的髋臼软骨，该技术能为我们提供有关软骨水分、胶原蛋白含量以及胶原纤维取向的信息。在全髋关节置换术中，从15例原发性骨关节炎患者（pOA - Ac）和15例DDH所致继发性骨关节炎患者（sOA - Ac）的髋臼中获取骨软骨单元样本。然后在一台7特斯拉的微型磁共振成像（micro - MRI）机器上对样本进行扫描，并计算所有样本的T2值。使用t检验对结果进行比较。sOA - Ac组和pOA - Ac组的平均T2值分别为57.28±31.87毫秒和37.54±11.17毫秒。计算得出的p值为0.019，使得结果在p<0.5时具有统计学意义。这是首批使用7特斯拉MRI机器对人类发育不良髋关节的髋臼软骨进行离体研究之一。我们的结果表明，DDH所致继发性骨关节炎中的髋臼软骨比原发性骨关节炎中的受损更严重，并提供了原发性和DDH所致继发性骨关节炎髋臼软骨的7特斯拉T2参考值。
