Activity of cefiderocol on extensively drug-resistant from burn wound infections in Mansoura, Egypt.

BACKGROUND AND OBJECTIVES

Increased antibiotic resistance limits treatment options and is associated with a higher level of mortality and mordacity. The purpose of this research was to identify class 1 and 2 integrons, carbapenemase, , and genes in extensively drug-resistant (XDR) isolated from infected burns and evaluate their in vitro cefiderocol activity.

MATERIALS AND METHODS

By using the disc diffusion method, the antimicrobial susceptibility of 110 isolates collected from infected burns were evaluated. XDR were screened phenotypically for carbapenemase and extended spectrum β-lactamases (ESBLs) production. Both MIC Test Strip and disc diffusion were employed to test the cefiderocol susceptibility. PCR was used to assess carbapenemase, and genes and integrons class 1 and 2.

RESULTS

From the 110 , 54 isolates (49%) were XDR. TEM gene was detected in 35 isolates. Among XDR isolates, carbapenemase genes were detected in 31.5%, with being predominant Thirty XDR isolates had class1 integrons. All isolates were sensitive to cefiderocol and its MIC/MIC was 0.5/1.5mg/L (range 0.064-1.5mg/L).

CONCLUSION

Nearly half the isolates from burn infections were extensively drug-resistant. Cefiderocol's in vitro activity demonstrated that it is a promising therapy alternative for treating extensively drug-resistant in burn patients.