实验性尿毒症中核黄素肠道吸收受损。

Impaired intestinal absorption of riboflavin in experimental uremia.

作者信息

Vaziri N D, Said H M, Hollander D, Barbari A, Patel N, Dang D, Kariger R

出版信息

Nephron. 1985;41(1):26-9. doi: 10.1159/000183541.

Abstract

Increased plasma and red blood cell concentrations of riboflavin have been reported in uremia. The possible role of altered intestinal absorption of riboflavin in the genesis of this abnormality is not known. For this reason we examined the intestinal absorption of riboflavin in rats made uremic by subtotal nephrectomy and sham-operated (control) rats in vivo using the recycling perfusion technique and in vitro using the everted-sac technique. Paradoxically, the results showed a significant impairment of intestinal absorption of riboflavin in vivo in uremic rats compared to the control group. However, no significant difference was observed in riboflavin transport in vitro. We conclude that the intestinal absorption of riboflavin is decreased in experimental uremia and cannot account for the reported increase in its plasma and red blood cell concentrations.

摘要

据报道，尿毒症患者血浆和红细胞中的核黄素浓度会升高。核黄素肠道吸收改变在这种异常情况发生过程中可能发挥的作用尚不清楚。因此，我们使用循环灌注技术在体内以及使用外翻肠囊技术在体外研究了通过肾大部切除造成尿毒症的大鼠和假手术（对照）大鼠肠道对核黄素的吸收情况。矛盾的是，结果显示，与对照组相比，尿毒症大鼠体内核黄素的肠道吸收显著受损。然而，体外核黄素转运未观察到显著差异。我们得出结论，实验性尿毒症时核黄素的肠道吸收减少，且不能解释所报道的其血浆和红细胞浓度升高的现象。