Pahl M V, Barbari A, Vaziri N D, Hollander D, Sanchez M, Oveisi F, Patel N
Department of Medicine, University of California, Irvine 92717.
Life Sci. 1990;46(23):1649-56. doi: 10.1016/0024-3205(90)90379-6.
The effect of renal failure (RF) on intestinal absorption of dietary fatty acids is not known. We studied the intestinal absorption of arachidonic acid (AA) in rats with experimental short-term (2 weeks post-subtotal nephrectomy) and long-term (5-6 weeks post-subtotal nephrectomy) RF. The results were compared with those obtained in sham-operated animals on liberal food intake (NL) and in those pair-fed (PF) with the respective RF groups. In vivo perfusion and in vitro incubation experiments were performed at a wide range of AA concentrations. The rates of AA transport determined both in vivo and in vitro were significantly lower in the short-term RF group than those found in the NL controls and the PF animals who showed comparable values. In contrast animals with long-term RF exhibited an increased rate of AA transport as compared with the respective controls. The observed changes in the transport rates appeared to parallel directional changes in mucosal mass which was reduced in animals with short-term RF and restored in those with long-term RF.
肾衰竭（RF）对膳食脂肪酸肠道吸收的影响尚不清楚。我们研究了实验性短期（次全肾切除术后2周）和长期（次全肾切除术后5 - 6周）RF大鼠对花生四烯酸（AA）的肠道吸收情况。将结果与自由进食的假手术动物（NL）以及与相应RF组配对喂养（PF）的动物所得结果进行比较。在广泛的AA浓度范围内进行了体内灌注和体外孵育实验。短期RF组体内和体外测定的AA转运速率均显著低于NL对照组和显示可比数值的PF动物。相反，与各自对照组相比，长期RF动物的AA转运速率有所增加。观察到的转运速率变化似乎与黏膜质量的方向性变化平行，短期RF动物的黏膜质量减少，而长期RF动物的黏膜质量恢复。
