Abel E L, Dintcheff B A
Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):263-6.
Despite relatively comparable amounts of alcohol ingestion, not all women who drink excessively give birth to children with fetal alcohol effects. The present study evaluated how maternal age affects the outcome of pregnancy in maternal rats of different ages. All dams were nulliparous and were 66, 121 or 156 days at time of treatment. Alcohol was administered at a dose of 3.5 g/kg, twice daily on gestation days 11-21. Alcohol had a greater impact on offspring born to older- and middle-age dams than to younger dams on a number of attributes including neonatal mortality and birth weight.
尽管摄入的酒精量相对相当，但并非所有酗酒的女性都会生下患有胎儿酒精影响的孩子。本研究评估了母鼠年龄如何影响不同年龄母鼠的妊娠结局。所有母鼠均未生育，治疗时年龄分别为66、121或156天。在妊娠第11至21天，每天两次以3.5克/千克的剂量给予酒精。在包括新生儿死亡率和出生体重在内的许多指标上，酒精对老年和中年母鼠所生后代的影响比对年轻母鼠所生后代的影响更大。
