Sterman A B, Sposito N
Neuropathol Appl Neurobiol. 1985 May-Jun;11(3):201-12. doi: 10.1111/j.1365-2990.1985.tb00018.x.
During acrylamide and hexacarbon exposure few changes have been reported in motoneuron perikarya. In the present study, light microscopic examination of lumbar motoneurons from rats intoxicated with either 2,5-hexanedione (2,5-HD) or acrylamide showed relatively few nonspecific changes compared to controls. However, ultrastructural study of 2,5-HD-intoxicated perikarya revealed a range of cytological reorganization: nuclear eccentricity and capping, reduced numbers of large Nissl bodies, and mitochondrial hypertrophy and hyperplasia. In 2,5-HD-intoxicated perikarya, computer-assisted stereologic analysis demonstrated a significant increase in the volume density of mitochondria. Ultrastructurally, acrylamide-intoxicated perikarya showed a marked reduction in the size of Nissl bodies. Stereologic analysis showed reductions in Nissl bodies, granular endoplasmic reticulum and Golgi complexes, and an increase in mitochondria. Taken together, these qualitative and morphometric changes, which were not obvious on light microscopic examination, imply significant reorganization of perikaryal metabolism.
在丙烯酰胺和己烷暴露期间，关于运动神经元胞体的变化报道较少。在本研究中，对用2,5 -己二酮（2,5 - HD）或丙烯酰胺中毒的大鼠腰段运动神经元进行光镜检查发现，与对照组相比，非特异性变化相对较少。然而，对2,5 - HD中毒胞体的超微结构研究揭示了一系列细胞学重组现象：核偏心和核帽形成、大的尼氏体数量减少、线粒体肥大和增生。在2,5 - HD中毒的胞体中，计算机辅助立体分析表明线粒体的体积密度显著增加。超微结构上，丙烯酰胺中毒的胞体显示尼氏体大小明显减小。立体分析显示尼氏体、粗面内质网和高尔基体复合体减少，线粒体增加。综上所述，这些在光镜检查中不明显的定性和形态计量学变化意味着胞体代谢的显著重组。
