Cavanagh J B, Gysbers M F
Acta Neuropathol. 1980;51(3):169-77. doi: 10.1007/BF00687383.
The application of a tight ligature around a nerve before daily administration of acrylamide (40 or 50 mg/kg) for 4 or 5 days leads to ascending degeneration of the injured nerves, the number of affected fibres and the degree of "dying back" being dependent on the dose of acrylamide given. The same response occurs whether acrylamide is given immediately after nerve ligation or 1 week later. Centripetal degeneration follows after a short delay period and is maximal at about 10 days after beginning acrylamide injections. The response is not found with INH, with misonidazole or with 2,5-hexanedione.
在每天给予丙烯酰胺（40或50毫克/千克），持续4或5天之前，对神经进行紧密结扎，会导致受损神经出现上行性变性，受影响纤维的数量以及“逆行性变性”的程度取决于所给予的丙烯酰胺剂量。无论在神经结扎后立即给予丙烯酰胺还是在1周后给予，都会出现相同的反应。向心性变性在短暂的延迟期后出现，在开始注射丙烯酰胺后约10天达到最大程度。异烟肼、米索硝唑或2,5 -己二酮不会出现这种反应。
