Wolfson L I, Leenders K L, Brown L L, Jones T
Neurology. 1985 Oct;35(10):1399-405. doi: 10.1212/wnl.35.10.1399.
Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) were determined in six normals, six unilateral Parkinson's disease (PD) patients, and eight bilateral PD patients. In the unilateral patients, rCBF and rCMRO2 in the basal ganglia contralateral to the symptomatic limbs was 13% higher than on the other side (p less than 0.01); in the frontal cortex it was 8% lower than the other side, suggesting abnormal neuronal function in both regions. The bilateral PD patients had a widespread decrease (20%) in rCBF unaccompanied by comparable changes in rCMRO2, suggesting vasoconstriction due to loss of dopaminergic innervation of blood vessels in more advanced PD patients.
对6名正常人、6名单侧帕金森病（PD）患者和8名双侧PD患者进行了局部脑血流量（rCBF）和氧代谢（rCMRO2）测定。在单侧患者中，与症状肢体对侧的基底节区的rCBF和rCMRO2比另一侧高13%（p<0.01）；在额叶皮质，其比另一侧低8%，提示这两个区域存在神经元功能异常。双侧PD患者的rCBF普遍降低（20%），而rCMRO2没有相应变化，提示在病情更严重的PD患者中，由于血管多巴胺能神经支配丧失导致血管收缩。
