Giudici Fabiola, Toffolutti Federica, Guzzinati Stefano, Schettini Francesco, Bortul Marina, Francisci Silvia, Zorzi Manuel, De Vidi Sara, Pierannunzio Daniela, Dal Maso Luigino
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Breast. 2025 May 1;82:104487. doi: 10.1016/j.breast.2025.104487.
BACKGROUND/AIM: Information on the long-term frequency of recurrence is of paramount importance for the increasing number of women living several years after breast cancer (BC) diagnosis and for their caregivers. The study aims to estimate the cumulative incidence of recurrence until 10 years after diagnosis in Italian women diagnosed with BC using population-based cancer registries.
Women diagnosed with stage I to III BC during 2004-2010 from Friuli Venezia Giulia and Veneto (Italy) cancer registries were included (n = 5825). Recurrence status after a disease-free period was ascertained through individual-level linked databases using treatment or procedure codes from claims. Cumulative incidence of recurrence was calculated in the presence of competing risks (second cancer or death).
During a median follow-up of 13.5 years, 1522 out of 5825 women experienced a recurrence with an estimated 10-years cumulative incidence of 20.8 % (95 %CI:19.7-21.8 %), decreasing from 23.7 % in 2004-2006 to 18.5 % in 2007-2010. Women younger than 40 years (40.5 %), with stage III (41.8 %) and triple-negative BC (32.5 %) showed a higher 10-year incidence of recurrence. At 10 years after a BC diagnosis, 83.9 % of women were alive: 67.5 % without any cancer-related events, 12.4 % after recurrence and 4.0 % after second primary cancer. 10-years survival was higher than 90 % for women with stage I BC and 58.1 % for those with stage III (3.2 % and 27.3 % deaths after recurrence, respectively).
This Italian study provide detailed population-based information on the incidence of recurrence and other outcomes after BC and may be replicated in other Italian and European areas.
背景/目的：对于越来越多在乳腺癌（BC）诊断后存活数年的女性及其护理人员而言，长期复发频率的信息至关重要。本研究旨在利用基于人群的癌症登记系统，估算意大利BC确诊女性诊断后至10年的复发累积发病率。
纳入2004 - 2010年期间在弗留利-威尼斯朱利亚和威尼托（意大利）癌症登记处确诊为I至III期BC的女性（n = 5825）。通过使用索赔中的治疗或程序代码的个体层面关联数据库，确定无病期后的复发状态。在存在竞争风险（二次癌症或死亡）的情况下计算复发累积发病率。
在中位随访13.5年期间，5825名女性中有1522名经历了复发，估计10年累积发病率为20.8%（95%CI：19.7 - 21.8%），从2004 - 2006年的23.7%降至2007 - 2010年的18.5%。年龄小于40岁的女性（40.5%）、III期女性（41.8%）和三阴性BC女性（32.5%）的10年复发率较高。在BC诊断后10年，83.9%的女性存活：67.5%无任何癌症相关事件，12.4%复发后存活，4.0%二次原发性癌症后存活。I期BC女性的10年生存率高于90%，III期女性为58.1%（复发后死亡分别为3.2%和27.3%）。
这项意大利研究提供了关于BC后复发率和其他结局的详细基于人群的信息，可在意大利其他地区和欧洲地区进行复制。
